SEPT2

From Wikipedia, the free encyclopedia

Septin 2

Identifiers

SEPT2; DIFF6; KIAA0158; NEDD5; hNedd5

External IDs

OMIM: 601506 MGI: 97298 HomoloGene: 3243

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• nucleus • cytoplasm • contractile ring • synaptosome
Biological Process:	• cytokinesis • cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001008491 (mRNA)
NP_001008491 (protein)

NM_010891 (mRNA)
NP_035021 (protein)

Location

Chr 2: 241.9 - 241.94 Mb

Chr 1: 95.31 - 95.34 Mb

Pubmed search

[1]

[2]

Septin 2, also known as SEPT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SEPT2 septin 2.

[edit] Further reading

Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.
Mori T, Miura K, Fujiwara T, et al. (1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6.". Cytogenet. Cell Genet. 73 (3): 224–7. PMID 8697812.
Kinoshita M, Kumar S, Mizoguchi A, et al. (1997). "Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures.". Genes Dev. 11 (12): 1535–47. PMID 9203580.
Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments.". Neuron 20 (6): 1111–22. PMID 9655500.
Kinoshita A, Kinoshita M, Akiyama H, et al. (1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease.". Am. J. Pathol. 153 (5): 1551–60. PMID 9811347.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Beites CL, Xie H, Bowser R, Trimble WS (1999). "The septin CDCrel-1 binds syntaxin and inhibits exocytosis.". Nat. Neurosci. 2 (5): 434–9. doi:10.1038/8100. PMID 10321247.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Sakai K, Kurimoto M, Tsugu A, et al. (2003). "Expression of Nedd5, a mammalian septin, in human brain tumors.". J. Neurooncol. 57 (3): 169–77. PMID 12125979.
Surka MC, Tsang CW, Trimble WS (2003). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis.". Mol. Biol. Cell 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMID 12388755.
Sheffield PJ, Oliver CJ, Kremer BE, et al. (2003). "Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments.". J. Biol. Chem. 278 (5): 3483–8. doi:10.1074/jbc.M209701200. PMID 12446710.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vega IE, Hsu SC (2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells.". Neuroreport 14 (1): 31–7. doi:10.1097/01.wnr.0000050304.92401.50. PMID 12544826.
Koshelev YA, Kiselev SL, Georgiev GP (2004). "Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro.". Dokl. Biochem. Biophys. 391: 195–7. PMID 14531065.
She YM, Huang YW, Zhang L, Trimble WS (2004). "Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo.". Rapid Commun. Mass Spectrom. 18 (10): 1123–30. doi:10.1002/rcm.1453. PMID 15150837.
Nagata K, Asano T, Nozawa Y, Inagaki M (2005). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.". J. Biol. Chem. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Spiliotis ET, Kinoshita M, Nelson WJ (2005). "A mitotic septin scaffold required for Mammalian chromosome congression and segregation.". Science 307 (5716): 1781–5. doi:10.1126/science.1106823. PMID 15774761.