SEPT1

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Septin 1
Identifiers
Symbol(s) SEPT1; DIFF6; LARP; MGC20394; PNUTL3; SEP1
External IDs MGI: 1858916 HomoloGene: 23009
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1731 54204
Ensembl ENSG00000180096 ENSMUSG00000000486
Uniprot Q8WYJ6 P42209
Refseq XM_001132049 (mRNA)
XP_001132049 (protein)		 NM_017461 (mRNA)
NP_059489 (protein)
Location Chr 16: 30.3 - 30.3 Mb Chr 7: 127.01 - 127.01 Mb
Pubmed search [1] [2]

Septin 1, also known as SEPT1, is a human gene.[1]

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[1]

[edit] References

  1. ^ a b Entrez Gene: SEPT1 septin 1.

[edit] Further reading

  • Nottenburg C, Gallatin WM, St John T (1991). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences.". Gene 95 (2): 279–84. PMID 2174398. 
  • Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280. 
  • Mori T, Miura K, Fujiwara T, et al. (1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6.". Cytogenet. Cell Genet. 73 (3): 224–7. PMID 8697812. 
  • Kinoshita A, Kinoshita M, Akiyama H, et al. (1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease.". Am. J. Pathol. 153 (5): 1551–60. PMID 9811347. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Qi M, Yu W, Liu S, et al. (2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B.". Biochem. Biophys. Res. Commun. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID 16179162. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kato Y, Uzawa K, Yamamoto N, et al. (2007). "Overexpression of Septin1: possible contribution to the development of oral cancer.". Int. J. Oncol. 31 (5): 1021–8. PMID 17912427. 
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