SEPSECS

From Wikipedia, the free encyclopedia

Soluble liver antigen/liver pancreas antigen

Identifiers

SLA/LP; MGC161491

External IDs

Gene ontology
Molecular Function:	• tRNA binding • protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• selenocysteine incorporation

Orthologs

Human

Mouse

Refseq

NM_016955 (mRNA)
NP_058651 (protein)

NM_172490 (mRNA)
NP_766078 (protein)

Location

Chr 4: 24.73 - 24.77 Mb

Chr 5: 52.93 - 52.96 Mb

Pubmed search

[1]

[2]

Soluble liver antigen/liver pancreas antigen, also known as SLA/LP, is a human gene.^[1]

[edit] References

^ Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen.

[edit] Further reading

Xu XM, Carlson BA, Mix H, et al. (2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes.". PLoS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMID 17194211.
Yuan J, Palioura S, Salazar JC, et al. (2007). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923-7. doi:10.1073/pnas.0609703104. PMID 17142313.
Xu XM, Mix H, Carlson BA, et al. (2006). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.". J. Biol. Chem. 280 (50): 41568-75. doi:10.1074/jbc.M506696200. PMID 16230358.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Herkel J, Heidrich B, Nieraad N, et al. (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas.". Hepatology 35 (2): 403-8. doi:10.1053/jhep.2002.30699. PMID 11826415.
Volkmann M, Martin L, Bäurle A, et al. (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis.". Hepatology 33 (3): 591-6. doi:10.1053/jhep.2001.22218. PMID 11230739.
Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients withtype-1 autoimmune hepatitis.". Clin. Exp. Immunol. 121 (2): 364-74. PMID 10931155.
Wies I, Brunner S, Henninger J, et al. (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis.". Lancet 355 (9214): 1510-5. PMID 10801173.