SEPP1

From Wikipedia, the free encyclopedia

Selenoprotein P, plasma, 1

Identifiers

SEPP1; SELP; SeP

External IDs

OMIM: 601484 MGI: 894288 HomoloGene: 3945

Gene ontology
Molecular Function:	• selenium binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• selenium metabolic process • response to oxidative stress • brain development • locomotory behavior • post-embryonic development • sexual reproduction • growth

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005410 (mRNA)
NP_005401 (protein)

NM_001042613 (mRNA)
NP_001036078 (protein)

Location

n/a

Chr 15: 3.22 - 3.23 Mb

Pubmed search

[1]

[2]

Selenoprotein P, plasma, 1, also known as SEPP1, is a human gene.^[1]

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEPP1 selenoprotein P, plasma, 1.

[edit] Further reading

Burk RF, Hill KE (1994). "Selenoprotein P. A selenium-rich extracellular glycoprotein.". J. Nutr. 124 (10): 1891–7. PMID 7931697.
Mostert V (2000). "Selenoprotein P: properties, functions, and regulation.". Arch. Biochem. Biophys. 376 (2): 433–8. doi:10.1006/abbi.2000.1735. PMID 10775431.
Hill KE, Lloyd RS, Yang JG, et al. (1991). "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame.". J. Biol. Chem. 266 (16): 10050–3. PMID 2037562.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Akesson B, Bellew T, Burk RF (1994). "Purification of selenoprotein P from human plasma.". Biochim. Biophys. Acta 1204 (2): 243–9. PMID 8142465.
Hill KE, Lloyd RS, Burk RF (1993). "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 537–41. PMID 8421687.
Hill KE, Dasouki M, Phillips JA, Burk RF (1997). "Human selenoprotein P gene maps to 5q31.". Genomics 36 (3): 550–1. PMID 8884283.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Mostert V, Lombeck I, Abel J (1998). "A novel method for the purification of selenoprotein P from human plasma.". Arch. Biochem. Biophys. 357 (2): 326–30. doi:10.1006/abbi.1998.0809. PMID 9735174.
Saito Y, Hayashi T, Tanaka A, et al. (1999). "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p.". J. Biol. Chem. 274 (5): 2866–71. PMID 9915822.
Koyama H, Omura K, Ejima A, et al. (1999). "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry.". Anal. Biochem. 267 (1): 84–91. doi:10.1006/abio.1998.2949. PMID 9918658.
Arteel GE, Franken S, Kappler J, Sies H (2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance.". Biol. Chem. 381 (3): 265–8. PMID 10782998.
Hondal RJ, Ma S, Caprioli RM, et al. (2001). "Heparin-binding histidine and lysine residues of rat selenoprotein P.". J. Biol. Chem. 276 (19): 15823–31. doi:10.1074/jbc.M010405200. PMID 11278668.
Nishimura K, Matsumiya K, Tsujimura A, et al. (2001). "Association of selenoprotein P with testosterone production in cultured Leydig cells.". Arch. Androl. 47 (1): 67–76. PMID 11442337.
Al-Taie OH, Seufert J, Mörk H, et al. (2003). "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency.". Eur. J. Hum. Genet. 10 (9): 499–504. doi:10.1038/sj.ejhg.5200811. PMID 12173025.
Saito Y, Takahashi K (2003). "Characterization of selenoprotein P as a selenium supply protein.". Eur. J. Biochem. 269 (22): 5746–51. PMID 12423375.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.