SENP2

From Wikipedia, the free encyclopedia

SUMO1/sentrin/SMT3 specific peptidase 2

PDB rendering based on 1tgz.

Available structures: 1tgz, 1th0, 2io0, 2io1, 2io2, 2io3

Identifiers

Symbol(s)

SENP2; AXAM2; DKFZp762A2316; KIAA1331; SMT3IP2

External IDs

OMIM: 608261 MGI: 1923076 HomoloGene: 11005

Gene ontology
Molecular Function:	• protein binding • cysteine-type peptidase activity • SUMO-specific protease activity
Cellular Component:	• nucleus • nuclear pore
Biological Process:	• proteolysis • ubiquitin cycle • protein desumoylation • regulation of Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021627 (mRNA)
NP_067640 (protein)

NM_029457 (mRNA)
NP_083733 (protein)

Location

Chr 3: 186.79 - 186.83 Mb

Chr 16: 21.92 - 21.96 Mb

Pubmed search

[1]

[2]

SUMO1/sentrin/SMT3 specific peptidase 2, also known as SENP2, is a human gene.^[1]

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2.

[edit] Further reading

Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.". J. Biol. Chem. 282 (36): 26217-24. PMID 17591783.
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.". Biochem J. 409 (2): 461-9. PMID 17916063.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Nishida T, Kaneko F, Kitagawa M, Yasuda H (2001). "Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation.". J. Biol. Chem. 276 (42): 39060-6. doi:10.1074/jbc.M103955200. PMID 11489887.
Hang J, Dasso M (2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore.". J. Biol. Chem. 277 (22): 19961-6. doi:10.1074/jbc.M201799200. PMID 11896061.
Kadoya T, Yamamoto H, Suzuki T, et al. (2002). "Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.". Mol. Cell. Biol. 22 (11): 3803-19. PMID 11997515.
Zhang H, Saitoh H, Matunis MJ (2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.". Mol. Cell. Biol. 22 (18): 6498-508. PMID 12192048.
Best JL, Ganiatsas S, Agarwal S, et al. (2002). "SUMO-1 protease-1 regulates gene transcription through PML.". Mol. Cell 10 (4): 843-55. PMID 12419228.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Reverter D, Lima CD (2005). "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.". Structure 12 (8): 1519-31. doi:10.1016/j.str.2004.05.023. PMID 15296745.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Itahana Y, Yeh ET, Zhang Y (2006). "Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2.". Mol. Cell. Biol. 26 (12): 4675-89. doi:10.1128/MCB.01830-05. PMID 16738331.
Reverter D, Lima CD (2007). "Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.". Nat. Struct. Mol. Biol. 13 (12): 1060-8. doi:10.1038/nsmb1168. PMID 17099700.