SENP1

From Wikipedia, the free encyclopedia

SUMO1/sentrin specific peptidase 1

PDB rendering based on 2ckg.

Available structures: 2ckg, 2ckh, 2g4d, 2iy0, 2iy1, 2iyc, 2iyd

Identifiers

Symbol(s)

SENP1; SuPr-2

External IDs

MGI: 2445054 HomoloGene: 8731

Gene ontology
Molecular Function:	• endopeptidase activity • cysteine-type peptidase activity
Cellular Component:	• nucleus
Biological Process:	• proteolysis • ubiquitin cycle • protein desumoylation

Orthologs

Human

Mouse

Refseq

NM_014554 (mRNA)
NP_055369 (protein)

NM_144851 (mRNA)
NP_659100 (protein)

Location

Chr 12: 46.72 - 46.79 Mb

Chr 15: 97.87 - 97.91 Mb

Pubmed search

[1]

[2]

SUMO1/sentrin specific peptidase 1, also known as SENP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SENP1 SUMO1/sentrin specific peptidase 1.

[edit] Further reading

Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.". J. Biol. Chem. 282 (36): 26217-24. PMID 17591783.
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.". Biochem J. 409 (2): 461-9. PMID 17916063.
Cheng J, Bawa T, Lee P, et al. (2006). "Role of desumoylation in the development of prostate cancer.". Neoplasia 8 (8): 667-76. doi:10.1593/neo.06445. PMID 16925949.
Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease.". J. Biol. Chem. 275 (5): 3355-9. PMID 10652325.
Bailey D, O'Hare P (2003). "Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.". J. Gen. Virol. 83 (Pt 12): 2951-64. PMID 12466471.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bailey D, O'Hare P (2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1.". J. Biol. Chem. 279 (1): 692-703. doi:10.1074/jbc.M306195200. PMID 14563852.
Cheng J, Wang D, Wang Z, Yeh ET (2004). "SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.". Mol. Cell. Biol. 24 (13): 6021-8. doi:10.1128/MCB.24.13.6021-6028.2004. PMID 15199155.
Xu Z, Au SW (2005). "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.". Biochem. J. 386 (Pt 2): 325-30. doi:10.1042/BJ20041210. PMID 15487983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Boggio R, Colombo R, Hay RT, et al. (2005). "A mechanism for inhibiting the SUMO pathway.". Mol. Cell 16 (4): 549-61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.
Cheng J, Perkins ND, Yeh ET (2005). "Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.". J. Biol. Chem. 280 (15): 14492-8. doi:10.1074/jbc.M412185200. PMID 15701643.
Rajan S, Plant LD, Rabin ML, et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1.". Cell 121 (1): 37-47. doi:10.1016/j.cell.2005.01.019. PMID 15820677.
Veltman IM, Vreede LA, Cheng J, et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).". Hum. Mol. Genet. 14 (14): 1955-63. doi:10.1093/hmg/ddi200. PMID 15917269.
Kim YH, Sung KS, Lee SJ, et al. (2005). "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.". FEBS Lett. 579 (27): 6272-8. doi:10.1016/j.febslet.2005.10.010. PMID 16253240.
Shen LN, Dong C, Liu H, et al. (2006). "The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.". Biochem. J. 397 (2): 279-88. doi:10.1042/BJ20052030. PMID 16553580.
Xu Z, Chau SF, Lam KH, et al. (2006). "Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease.". Biochem. J. 398 (3): 345-52. doi:10.1042/BJ20060526. PMID 16712526.
Shen L, Tatham MH, Dong C, et al. (2007). "SUMO protease SENP1 induces isomerization of the scissile peptide bond.". Nat. Struct. Mol. Biol. 13 (12): 1069-77. doi:10.1038/nsmb1172. PMID 17099698.