SEMA6A

From Wikipedia, the free encyclopedia

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

Identifiers

SEMA6A; HT018; KIAA1368; SEMA; SEMA6A1; SEMAQ; VIA; sema VIa

External IDs

OMIM: 605885 MGI: 1203727 HomoloGene: 32426

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane • axon
Biological Process:	• apoptosis • cytoskeleton organization and biogenesis • cell surface receptor linked signal transduction • multicellular organismal development • nervous system development • axon guidance • organ morphogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020796 (mRNA)
NP_065847 (protein)

NM_018744 (mRNA)
NP_061214 (protein)

Location

Chr 5: 115.81 - 115.94 Mb

Chr 18: 47.37 - 47.49 Mb

Pubmed search

[1]

[2]

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, also known as SEMA6A, is a human gene.^[1]

[edit] References

^ Entrez Gene: SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A.

[edit] Further reading

Prislei S, Mozzetti S, Filippetti F, et al. (2008). "From plasma membrane to cytoskeleton: a novel function for semaphorin 6A.". Mol. Cancer Ther. 7 (1): 233-41. doi:10.1158/1535-7163.MCT-07-0390. PMID 18187809.
Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells.". Int. J. Mol. Med. 20 (3): 405-9. PMID 17671748.
Gautier G, de Saint-Vis B, Sénéchal B, et al. (2006). "The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations.". Am. J. Pathol. 168 (2): 453-65. PMID 16436660.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Klostermann A, Lutz B, Gertler F, Behl C (2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain.". J. Biol. Chem. 275 (50): 39647-53. doi:10.1074/jbc.M006316200. PMID 10993894.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Zhou L, White FA, Lentz SI, et al. (1997). "Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I.". Mol. Cell. Neurosci. 9 (1): 26-41. doi:10.1006/mcne.1997.0607. PMID 9204478.