SEMA5A

From Wikipedia, the free encyclopedia

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

Identifiers

Symbol(s)

SEMA5A; SEMAF; semF

External IDs

OMIM: 609297 MGI: 107556 HomoloGene: 2949

Gene ontology
Molecular Function:	• receptor activity • axon guidance receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• patterning of blood vessels • cell adhesion • cell-cell signaling • multicellular organismal development • nervous system development • axon guidance • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003966 (mRNA)
NP_003957 (protein)

NM_009154 (mRNA)
NP_033180 (protein)

Location

Chr 5: 9.09 - 9.6 Mb

Chr 15: 32.19 - 32.64 Mb

Pubmed search

[1]

[2]

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A, also known as SEMA5A, is a human gene.^[1]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A.

[edit] Further reading

Adams RH, Betz H, Püschel AW (1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis.". Mech. Dev. 57 (1): 33–45. PMID 8817451.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.". Genome Res. 7 (2): 118–27. PMID 9049630.
Simmons AD, Püschel AW, McPherson JD, et al. (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval.". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A.". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMID 15218527.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism.". Neuropsychobiology 54 (1): 64–9. doi:10.1159/000096040. PMID 17028446.