SEMA4G

From Wikipedia, the free encyclopedia

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Identifiers

SEMA4G; FLJ20590; KIAA1619; MGC102867

External IDs

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• multicellular organismal development • nervous system development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017893 (mRNA)
NP_060363 (protein)

NM_011976 (mRNA)
NP_036106 (protein)

Location

Chr 10: 102.72 - 102.74 Mb

Chr 19: 45.04 - 45.06 Mb

Pubmed search

[1]

[2]

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G, also known as SEMA4G, is a human gene.^[1]

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G.

[edit] Further reading

Pasterkamp RJ, Kolodkin AL (2003). "Semaphorin junction: making tracks toward neural connectivity.". Curr. Opin. Neurobiol. 13 (1): 79-89. PMID 12593985.
Dickson BJ (2003). "Molecular mechanisms of axon guidance.". Science 298 (5600): 1959-64. doi:10.1126/science.1072165. PMID 12471249.
Holtmaat AJ, De Winter F, De Wit J, et al. (2002). "Semaphorins: contributors to structural stability of hippocampal networks?". Prog. Brain Res. 138: 17-38. PMID 12432760.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.