SEMA4A

From Wikipedia, the free encyclopedia

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Identifiers

SEMA4A; CORD10; FLJ12287; RP11-54H19.2; RP35; SEMAB; SEMB

External IDs

OMIM: 607292 MGI: 107560 HomoloGene: 8425

Gene ontology
Molecular Function:	• DNA binding • receptor activity • ATP binding • DNA-dependent ATPase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• DNA metabolic process • multicellular organismal development • nervous system development • visual perception • cell differentiation • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022367 (mRNA)
NP_071762 (protein)

NM_013658 (mRNA)
NP_038686 (protein)

Location

Chr 1: 154.39 - 154.41 Mb

Chr 3: 88.52 - 88.54 Mb

Pubmed search

[1]

[2]

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, also known as SEMA4A, is a human gene.^[1]

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A.

[edit] Further reading

Kikutani H, Kumanogoh A (2003). "Semaphorins in interactions between T cells and antigen-presenting cells.". Nat. Rev. Immunol. 3 (2): 159–67. doi:10.1038/nri1003. PMID 12563299.
Kumanogoh A, Kikutani H (2004). "Immune semaphorins: a new area of semaphorin research.". J. Cell. Sci. 116 (Pt 17): 3463–70. doi:10.1242/jcs.00674. PMID 12893810.
Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, et al. (2004). "Structure and function of the immune semaphorin CD100/SEMA4D.". Crit. Rev. Immunol. 23 (1-2): 65–81. PMID 12906260.
Püschel AW, Adams RH, Betz H (1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.". Neuron 14 (5): 941–8. PMID 7748561.
Kumanogoh A, Marukawa S, Suzuki K, et al. (2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.". Nature 419 (6907): 629–33. doi:10.1038/nature01037. PMID 12374982.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Abid A, Ismail M, Mehdi SQ, Khaliq S (2006). "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases.". J. Med. Genet. 43 (4): 378–81. doi:10.1136/jmg.2005.035055. PMID 16199541.