Selamectin
From Wikipedia, the free encyclopedia
| Selamectin | |
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| Identifiers | |
| CAS number | [165108-07-6] |
| PubChem | |
| SMILES | CC1CCC2(CC3CC(O2)CC= C(C(C(C=CC=C4COC5C4(C(C= C(C5=NO)C)C(=O)O3)O)C) OC6CC(C(C(O6)C)O) OC)C)OC1C7CCCCC7 |
| Properties | |
| Molecular formula | C43H63NO11 |
| Molar mass | 769.96 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Selamectin is the active ingredient in Revolution, a topical insecticide and antihelminthic used on dogs and cats. It controls fleas, heartworm, hookworms, roundworms, and ear mites.
Selamectin achieves efficacy by replacing glutamate which normally interacts with receptors that open chloride channels at muscle synapses found in parasites. Unlike glutamate, selamectin activates the chloride current without desensitization, thereby producing prolonged hyperpolarization and impaired muscle contraction.
