SELT

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Selenoprotein T
Identifiers
Symbol(s) SELT;
External IDs OMIM: 607912 HomoloGene: 32304
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51714 n/a
Ensembl ENSG00000198843 n/a
Uniprot P62341 n/a
Refseq NM_016275 (mRNA)
NP_057359 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 3: 151.8 - 151.83 Mb n/a
Pubmed search [1] n/a

Selenoprotein T, also known as SELT, is a human gene.[1]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[1]

[edit] References

  1. ^ a b Entrez Gene: SELT selenoprotein T.

[edit] Further reading

  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Kryukov GV, Castellano S, Novoselov SV, et al. (2003). "Characterization of mammalian selenoproteomes.". Science 300 (5624): 1439-43. doi:10.1126/science.1083516. PMID 12775843. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kryukov GV, Kryukov VM, Gladyshev VN (1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.". J. Biol. Chem. 274 (48): 33888-97. PMID 10567350. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. 
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