SEDLP

From Wikipedia, the free encyclopedia

Spondyloepiphyseal dysplasia, late, pseudogene

Identifiers

SEDLP; MIP-2A; SEDLP1

Gene ontology

Orthologs

Human

Mouse

Entrez

10597

n/a

Pubmed search

[1]

n/a

Spondyloepiphyseal dysplasia, late, pseudogene, also known as SEDLP, is a human gene.^[1]

This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene.

[edit] Further reading

Sacher M (2003). "Membrane traffic fuses with cartilage development.". FEBS Lett. 550 (1-3): 1–4. PMID 12935876.
Gécz J, Hillman MA, Gedeon AK, et al. (2001). "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda.". Genomics 69 (2): 242–51. doi:10.1006/geno.2000.6326. PMID 11031107.
Ghosh AK, Majumder M, Steele R, et al. (2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.". Mol. Cell. Biol. 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. PMID 11134351.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ghosh AK, Steele R, Ray RB (2003). "Modulation of human luteinizing hormone beta gene transcription by MIP-2A.". J. Biol. Chem. 278 (26): 24033–8. doi:10.1074/jbc.M211982200. PMID 12700240.
Savarirayan R, Thompson E, Gécz J (2004). "Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).". Eur. J. Hum. Genet. 11 (9): 639–42. doi:10.1038/sj.ejhg.5201025. PMID 12939648.
Gécz J, Shaw MA, Bellon JR, de Barros Lopes M (2004). "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.". Gene 320: 137–44. PMID 14597397.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.