Secretoglobin, family 1A, member 1 (uteroglobin)

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Secretoglobin, family 1A, member 1 (uteroglobin)
Identifiers
Symbol(s) SCGB1A1; CC10; CC16; CCSP; UGB
External IDs OMIM: 192020 MGI: 98919 HomoloGene: 2518
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7356 22287
Ensembl ENSG00000149021 ENSMUSG00000024653
Uniprot P11684 Q3UKV9
Refseq NM_003357 (mRNA)
NP_003348 (protein)		 NM_011681 (mRNA)
NP_035811 (protein)
Location Chr 11: 61.94 - 61.95 Mb Chr 19: 9.15 - 9.15 Mb
Pubmed search [1] [2]

The founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals.[1] This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: Uteroglobin (UG, UGB), Uteroglobin-like Antigen (UGL), Blastokinin, Clara cell secretory protein (CCSP), Clara cell 16 kD protein (17 in rat/mice), Clara Cell-Specific 10 kD Protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human Clara Cell Phospholipid-Binding Protein (hCCPBP), Secretoglobin 1A member 1 (SCGB1A1).[2]

Contents

[edit] Function

Real physiological role is not known. Putative functions are:

  1. Immunomodulation:
  2. Progesterone binding: weak in some animals, especially weak in humans. (Note: UGB is itself progesterone induced gene in the endometrium.)
  3. Inhibits phospholipase A2
  4. binds phosphatidylcholine, phosphatidylinositol,
  5. Binds to fibronectin: The uteroglobulin knockout mice develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect[3]
  6. Target of Polychlorinated biphenyl (pcb) binding

[edit] External links

[edit] References

  1. ^ Laukaitis CM, Karn RC (2005). "Evolution of the secretoglobins: a genomic and proteomic view". Biological Journal of the Linnean Society 84 (3): 493–501. doi:10.1111/j.1095-8312.2005.00450.x. 
  2. ^ Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Ann. N. Y. Acad. Sci. 923: 348–54. doi:10.1111/j.1095-8312.2005.00450.x. PMID 11193777. 
  3. ^ Vollmer M, Krapf R, Hildebrandt F (1998). "Exclusion of the uteroglobin gene as a candidate for fibronectin glomerulopathy (GFND)". Nephrol. Dial. Transplant. 13 (9): 2417–8. doi:10.1093/ndt/13.9.2417. PMID 9761542. 

[edit] Further reading

  • Wolf M, Klug J, Hackenberg R, et al. (1993). "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines.". Hum. Mol. Genet. 1 (6): 371–8. PMID 1284526. 
  • Bernard A, Roels H, Lauwerys R, et al. (1992). "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions.". Clin. Chim. Acta 207 (3): 239–49. PMID 1395029. 
  • Singh G, Katyal SL, Brown WE, et al. (1988). "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein.". Biochim. Biophys. Acta 950 (3): 329–37. PMID 3167058. 
  • Singh G, Singh J, Katyal SL, et al. (1988). "Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein.". J. Histochem. Cytochem. 36 (1): 73–80. PMID 3275712. 
  • Jensen SM, Jones JE, Pass H, et al. (1994). "Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium.". Int. J. Cancer 58 (5): 629–37. PMID 7521325. 
  • Umland TC, Swaminathan S, Singh G, et al. (1995). "Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution.". Nat. Struct. Biol. 1 (8): 538–45. PMID 7664082. 
  • Hay JG, Danel C, Chu CS, Crystal RG (1995). "Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.". Am. J. Physiol. 268 (4 Pt 1): L565–75. PMID 7733299. 
  • Zhang Z, Zimonjic DB, Popescu NC, et al. (1997). "Human uteroglobin gene: structure, subchromosomal localization, and polymorphism.". DNA Cell Biol. 16 (1): 73–83. PMID 9022046. 
  • Laing IA, Goldblatt J, Eber E, et al. (1998). "A polymorphism of the CC16 gene is associated with an increased risk of asthma.". J. Med. Genet. 35 (6): 463–7. PMID 9643286. 
  • Zheng F, Kundu GC, Zhang Z, et al. (1999). "Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice.". Nat. Med. 5 (9): 1018–25. doi:10.1038/12458. PMID 10470078. 
  • Müller-Schöttle F, Classen-Linke I, Alfer J, et al. (2000). "Expression of uteroglobin in the human endometrium.". Mol. Hum. Reprod. 5 (12): 1155–61. PMID 10587371. 
  • Kundu GC, Zhang Z, Mantile-Selvaggi G, et al. (2001). "Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.". Ann. N. Y. Acad. Sci. 923: 234–48. PMID 11193760. 
  • Burmeister R, Boe IM, Nykjaer A, et al. (2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.". J. Biol. Chem. 276 (16): 13295–301. doi:10.1074/jbc.M010679200. PMID 11278724. 
  • Matsunaga A, Numakura C, Kawakami T, et al. (2002). "Association of the uteroglobin gene polymorphism with IgA nephropathy.". Am. J. Kidney Dis. 39 (1): 36–41. PMID 11774099. 
  • Ghafouri B, Ståhlbom B, Tagesson C, Lindahl M (2002). "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.". Proteomics 2 (1): 112–20. PMID 11788998. 
  • Narita I, Saito N, Goto S, et al. (2002). "Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients.". Kidney Int. 61 (5): 1853–8. doi:10.1046/j.1523-1755.2002.00336.x. PMID 11967037. 
  • Shijubo N, Itoh Y, Abe S (2002). "[Anti-inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases]". Rinsho Byori 50 (4): 370–3. PMID 12014016. 
  • Chowdhury B, Mantile-Selvaggi G, Miele L, et al. (2002). "Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.". Biochem. Biophys. Res. Commun. 295 (4): 877–83. PMID 12127976. 
  • Coppo R, Chiesa M, Cirina P, et al. (2002). "In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice.". Am. J. Kidney Dis. 40 (3): 495–503. PMID 12200800. 
  • Navab R, Wang Y, Chow YH, et al. (2002). "Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs).". Am. J. Respir. Cell Mol. Biol. 27 (3): 273–85. PMID 12204889. 
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