Secretin receptor

From Wikipedia, the free encyclopedia

Secretin receptor

Identifiers

External IDs

OMIM: 182098 HomoloGene: 68290

Gene ontology
Molecular Function:	• receptor activity • G-protein coupled receptor activity • vasoactive intestinal polypeptide receptor activity • secretin receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • digestion • excretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002980 (mRNA)
NP_002971 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 2: 119.91 - 120 Mb

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Pubmed search

[1]

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Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.^[1]

[edit] References

^ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Recept. Channels 8 (3-4): 189–200. PMID 12529936.

[edit] Further reading

Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.". Gastroenterology 114 (2): 382–97. PMID 9453500.
Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692.
Ishihara T, Nakamura S, Kaziro Y, et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor.". EMBO J. 10 (7): 1635–41. PMID 1646711.
Robberecht P, De Neef P, Waelbroeck M, et al. (1988). "Secretin receptors in human pancreatic membranes.". Pancreas 3 (5): 529–35. PMID 3186683.
Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor.". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008.
Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor.". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244.
Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.". J. Biol. Chem. 270 (24): 14394–8. PMID 7782300.
Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor.". Biochem. Biophys. Res. Commun. 207 (3): 883–90. PMID 7864894.
Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.". Genomics 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789.
Vilardaga JP, di Paolo E, de Neef P, et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602.
Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor.". Receptors & signal transduction 7 (3): 143–50. PMID 9440501.
Shetzline MA, Premont RT, Walker JK, et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.". J. Biol. Chem. 273 (12): 6756–62. PMID 9506976.
Ho PK, Fong RS, Kai HS, et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization.". FEBS Lett. 455 (3): 209–14. PMID 10437774.
Pang RT, Ng SS, Cheng CH, et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor.". Endocrinology 140 (11): 5102–11. PMID 10537138.
Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.". Endocrinology 142 (9): 3926–34. PMID 11517171.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pang RT, Lee LT, Ng SS, et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

[edit] External links

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened