SECISBP2

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SECIS binding protein 2
Identifiers
Symbol(s) SECISBP2; DKFZp686C09169; SBP2
External IDs OMIM: 607693 MGI: 1922670 HomoloGene: 11415
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79048 75420
Ensembl ENSG00000187742 ENSMUSG00000035139
Uniprot Q96T21 n/a
Refseq NM_024077 (mRNA)
NP_076982 (protein)		 XM_127336 (mRNA)
XP_127336 (protein)
Location Chr 9: 91.12 - 91.16 Mb Chr 13: 51.66 - 51.7 Mb
Pubmed search [1] [2]

SECIS binding protein 2, also known as SECISBP2, is a human gene.[1]

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: SECISBP2 SECIS binding protein 2.

[edit] Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Copeland PR, Fletcher JE, Carlson BA, et al. (2000). "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs.". EMBO J. 19 (2): 306-14. doi:10.1093/emboj/19.2.306. PMID 10637234. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Low SC, Grundner-Culemann E, Harney JW, Berry MJ (2001). "SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy.". EMBO J. 19 (24): 6882-90. doi:10.1093/emboj/19.24.6882. PMID 11118223. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Lescure A, Allmang C, Yamada K, et al. (2002). "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2.". Gene 291 (1-2): 279-85. PMID 12095701. 
  • Allmang C, Carbon P, Krol A (2002). "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding.". RNA 8 (10): 1308-18. PMID 12403468. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Dumitrescu AM, Liao XH, Abdullah MS, et al. (2006). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism.". Nat. Genet. 37 (11): 1247-52. doi:10.1038/ng1654. PMID 16228000. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Papp LV, Lu J, Striebel F, et al. (2006). "The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function.". Mol. Cell. Biol. 26 (13): 4895-910. doi:10.1128/MCB.02284-05. PMID 16782878. 
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