SEC61G

From Wikipedia, the free encyclopedia

Sec61 gamma subunit

Identifiers

External IDs

OMIM: 609215 MGI: 1202066 HomoloGene: 40767

Gene ontology
Molecular Function:	• protein transmembrane transporter activity
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• protein targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012456 (mRNA)
NP_001012474 (protein)

NM_011343 (mRNA)
NP_035473 (protein)

Location

Chr 7: 54.79 - 54.79 Mb

Chr 9: 37 - 37 Mb

Pubmed search

[1]

[2]

Sec61 gamma subunit, also known as SEC61G, is a human gene.^[1]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC61G Sec61 gamma subunit.

[edit] Further reading

Hartmann E, Sommer T, Prehn S, et al. (1994). "Evolutionary conservation of components of the protein translocation complex.". Nature 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851.
Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.". Nature 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469.
Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.". J. Biol. Chem. 273 (19): 11887–94. PMID 9565615.
Greenfield JJ, High S (1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.". J. Cell. Sci. 112 ( Pt 10): 1477–86. PMID 10212142.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.