SEC31A

From Wikipedia, the free encyclopedia

SEC31 homolog A (S. cerevisiae)

Identifiers

SEC31A; ABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; SEC31L1

External IDs

OMIM: 610257 MGI: 1916412 HomoloGene: 42056

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• COPII vesicle coat
Biological Process:	• ER to Golgi vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001077206 (mRNA)
NP_001070674 (protein)

XM_132230 (mRNA)
XP_132230 (protein)

Location

Chr 4: 83.96 - 84.04 Mb

Chr 5: 100.6 - 100.66 Mb

Pubmed search

[1]

[2]

SEC31 homolog A (S. cerevisiae), also known as SEC31A, is a human gene.^[1]

The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC31A SEC31 homolog A (S. cerevisiae).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485.
Tang BL, Zhang T, Low DY, et al. (2000). "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.". J. Biol. Chem. 275 (18): 13597-604. PMID 10788476.
Kim JH, Hong JA, Pih KT, Hwang I (2001). "Identification and isolation of differentially expressed genes in osmotically stressed human oral keratinocytes.". Arch. Oral Biol. 46 (4): 335-41. PMID 11269867.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333-44. doi:10.1091/mbc.E03-12-0878. PMID 15146057.
Panagopoulos I, Nilsson T, Domanski HA, et al. (2006). "Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.". Int. J. Cancer 118 (5): 1181-6. doi:10.1002/ijc.21490. PMID 16161041.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Stagg SM, Gürkan C, Fowler DM, et al. (2006). "Structure of the Sec13/31 COPII coat cage.". Nature 439 (7073): 234-8. doi:10.1038/nature04339. PMID 16407955.
Yamasaki A, Tani K, Yamamoto A, et al. (2007). "The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.". Mol. Biol. Cell 17 (11): 4876-87. doi:10.1091/mbc.E06-05-0444. PMID 16957052.
Shibata H, Suzuki H, Yoshida H, Maki M (2007). "ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.". Biochem. Biophys. Res. Commun. 353 (3): 756-63. doi:10.1016/j.bbrc.2006.12.101. PMID 17196169.
la Cour JM, Mollerup J, Berchtold MW (2007). "ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations.". Biochem. Biophys. Res. Commun. 353 (4): 1063-7. doi:10.1016/j.bbrc.2006.12.143. PMID 17214967.