SEC24D

From Wikipedia, the free encyclopedia

SEC24 related gene family, member D (S. cerevisiae)

Identifiers

SEC24D; FLJ43974; KIAA0755

External IDs

OMIM: 607186 MGI: 1916858 HomoloGene: 40986

Gene ontology
Molecular Function:	• molecular_function • protein binding • zinc ion binding
Cellular Component:	• endoplasmic reticulum • COPII vesicle coat
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_014822 (mRNA)
NP_055637 (protein)

NM_027135 (mRNA)
NP_081411 (protein)

Location

Chr 4: 119.86 - 119.98 Mb

Chr 3: 123.26 - 123.36 Mb

Pubmed search

[1]

[2]

SEC24 related gene family, member D (S. cerevisiae), also known as SEC24D, is a human gene.^[1]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae).

[edit] Further reading

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem. 274 (12): 7833–40. PMID 10075675.
Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p.". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin.". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMID 15580264.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.