SEC24B

From Wikipedia, the free encyclopedia

SEC24 related gene family, member B (S. cerevisiae)

Identifiers

SEC24B; MGC48822; SEC24

External IDs

OMIM: 607184 MGI: 2139764 HomoloGene: 55968

Gene ontology
Molecular Function:	• transporter activity • protein binding • zinc ion binding
Cellular Component:	• endoplasmic reticulum • membrane • COPII vesicle coat
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle-mediated transport

Orthologs

Human

Mouse

n/a

Refseq

XM_001130118 (mRNA)
XP_001130118 (protein)

XM_916502 (mRNA)
XP_921595 (protein)

Location

n/a

Chr 3: 129.98 - 130.05 Mb

Pubmed search

[1]

[2]

SEC24 related gene family, member B (S. cerevisiae), also known as SEC24B, is a human gene.^[1]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae).

[edit] Further reading

Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.". Mol. Cell 26 (3): 403-14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p.". Biochem. Biophys. Res. Commun. 258 (3): 679-84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem. 274 (12): 7833-40. PMID 10075675.