SEC23IP

From Wikipedia, the free encyclopedia

SEC23 interacting protein

Identifiers

SEC23IP; MSTP053; P125

External IDs

Gene ontology
Molecular Function:	• protein binding • metal ion binding
Cellular Component:	• cytoplasm • endoplasmic reticulum • ER-Golgi intermediate compartment
Biological Process:	• intracellular protein transport • Golgi organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007190 (mRNA)
NP_009121 (protein)

NM_001029982 (mRNA)
NP_001025153 (protein)

Location

Chr 10: 121.64 - 121.69 Mb

Chr 7: 128.54 - 128.57 Mb

Pubmed search

[1]

[2]

SEC23 interacting protein, also known as SEC23IP, is a human gene.^[1]

COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC23IP SEC23 interacting protein.

[edit] Further reading

Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta.". J. Biol. Chem. 281 (21): 14748-55. doi:10.1074/jbc.M600322200. PMID 16510448.
Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization.". J. Biol. Chem. 280 (11): 10141-8. doi:10.1074/jbc.M409673200. PMID 15623529.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein.". Biochem. Biophys. Res. Commun. 279 (1): 144-9. doi:10.1006/bbrc.2000.3846. PMID 11112430.
Tani K, Mizoguchi T, Iwamatsu A, et al. (1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins.". J. Biol. Chem. 274 (29): 20505-12. PMID 10400679.