SEC23B

From Wikipedia, the free encyclopedia

Sec23 homolog B (S. cerevisiae)

Identifiers

External IDs

OMIM: 610512 MGI: 1350925 HomoloGene: 74571

Gene ontology
Molecular Function:	• protein binding • zinc ion binding
Cellular Component:	• endoplasmic reticulum • membrane • COPII vesicle coat • perinuclear region of cytoplasm
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006363 (mRNA)
NP_006354 (protein)

NM_019787 (mRNA)
NP_062761 (protein)

Location

Chr 20: 18.44 - 18.49 Mb

Chr 2: 144.25 - 144.28 Mb

Pubmed search

[1]

[2]

Sec23 homolog B (S. cerevisiae), also known as SEC23B, is a human gene.^[1]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae).

[edit] Further reading

Paccaud JP, Reith W, Carpentier JL, et al. (1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23.". Mol. Biol. Cell 7 (10): 1535–46. PMID 8898360.
Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem. 274 (12): 7833–40. PMID 10075675.
Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p.". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.