SEC14L2

From Wikipedia, the free encyclopedia

SEC14-like 2 (S. cerevisiae)

PDB rendering based on 1o6u.

Available structures: 1o6u, 1olm

Identifiers

Symbol(s)

SEC14L2; TAP; TAP1; C22orf6; KIAA1186; KIAA1658; MGC65053; SPF

External IDs

OMIM: 607558 MGI: 1915065 HomoloGene: 8245

Gene ontology
Molecular Function:	• transporter activity • phospholipid binding • protein carrier activity • vitamin E binding • transcription activator activity
Cellular Component:	• intracellular • nucleus • cytoplasm • integral to membrane
Biological Process:	• transcription • transport • regulation of cholesterol biosynthetic process • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012429 (mRNA)
NP_036561 (protein)

NM_144520 (mRNA)
NP_653103 (protein)

Location

Chr 22: 29.12 - 29.15 Mb

Chr 11: 4 - 4.02 Mb

Pubmed search

[1]

[2]

SEC14-like 2 (S. cerevisiae), also known as SEC14L2, is a human gene.^[1]

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae).

[edit] Further reading

Caras IW, Friedlander EJ, Bloch K (1980). "Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids.". J. Biol. Chem. 255 (8): 3575-80. PMID 7364757.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Solheim JC, Harris MR, Kindle CS, Hansen TH (1997). "Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing.". J. Immunol. 158 (5): 2236-41. PMID 9036970.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Zimmer S, Stocker A, Sarbolouki MN, et al. (2000). "A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization.". J. Biol. Chem. 275 (33): 25672-80. doi:10.1074/jbc.M000851200. PMID 10829015.
Shibata N, Arita M, Misaki Y, et al. (2001). "Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2244-9. doi:10.1073/pnas.041620398. PMID 11226224.
Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.". DNA Res. 8 (1): 1-9. PMID 11258795.
Yamauchi J, Iwamoto T, Kida S, et al. (2001). "Tocopherol-associated protein is a ligand-dependent transcriptional activator.". Biochem. Biophys. Res. Commun. 285 (2): 295-9. doi:10.1006/bbrc.2001.5162. PMID 11444841.
Stocker A, Tomizaki T, Schulze-Briese C, Baumann U (2003). "Crystal structure of the human supernatant protein factor.". Structure 10 (11): 1533-40. PMID 12429094.
Singh DK, Mokashi V, Elmore CL, Porter TD (2003). "Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.". J. Biol. Chem. 278 (8): 5646-51. doi:10.1074/jbc.M211750200. PMID 12454003.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kempná P, Zingg JM, Ricciarelli R, et al. (2004). "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties.". Free Radic. Biol. Med. 34 (11): 1458-72. PMID 12757856.
Stocker A, Baumann U (2003). "Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis.". J. Mol. Biol. 332 (4): 759-65. PMID 12972248.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mokashi V, Singh DK, Porter TD (2004). "Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.". Biochem. Biophys. Res. Commun. 316 (3): 688-92. doi:10.1016/j.bbrc.2004.02.103. PMID 15033454.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149-54. doi:10.1126/science.1108625. PMID 15790807.