SDC4

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Syndecan 4
PDB rendering based on 1ejp.
Available structures: 1ejp, 1ejq
Identifiers
Symbol(s) SDC4; MGC22217; SYND4
External IDs OMIM: 600017 MGI: 1349164 HomoloGene: 31121
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6385 20971
Ensembl ENSG00000124145 ENSMUSG00000017009
Uniprot P31431 Q3U5S6
Refseq NM_002999 (mRNA)
NP_002990 (protein)		 NM_011521 (mRNA)
NP_035651 (protein)
Location Chr 20: 43.39 - 43.41 Mb Chr 2: 164.12 - 164.13 Mb
Pubmed search [1] [2]

Syndecan 4, also known as SDC4, is a human gene.

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.[1]

[edit] References

  1. ^ Entrez Gene: SDC4 syndecan 4.

[edit] Further reading

  • Bass MD, Humphries MJ (2002). "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling.". Biochem. J. 368 (Pt 1): 1–15. doi:10.1042/BJ20021228. PMID 12241528. 
  • David G, van der Schueren B, Marynen P, et al. (1992). "Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.". J. Cell Biol. 118 (4): 961–9. PMID 1500433. 
  • Yu H, Humphries DE, Watkins M, Karlinsky JB (1995). "Molecular cloning of the human ryudocan promoter.". Biochem. Biophys. Res. Commun. 212 (3): 1139–44. PMID 7626103. 
  • Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. PMID 7690138. 
  • Kojima T, Inazawa J, Takamatsu J, et al. (1993). "Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.". Biochem. Biophys. Res. Commun. 190 (3): 814–22. doi:10.1006/bbrc.1993.1122. PMID 7916598. 
  • Woods A, Couchman JR (1994). "Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component.". Mol. Biol. Cell 5 (2): 183–92. PMID 8019004. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor.". Oncogene 12 (2): 289–97. PMID 8570206. 
  • Kojima T, Katsumi A, Yamazaki T, et al. (1996). "Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor.". J. Biol. Chem. 271 (10): 5914–20. PMID 8621465. 
  • Takagi A, Kojima T, Tsuzuki S, et al. (1997). "Structural organization and promoter activity of the human ryudocan gene.". J. Biochem. 119 (5): 979–84. PMID 8797100. 
  • Rusnati M, Coltrini D, Oreste P, et al. (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size.". J. Biol. Chem. 272 (17): 11313–20. PMID 9111037. 
  • Chang HC, Samaniego F, Nair BC, et al. (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region.". AIDS 11 (12): 1421–31. PMID 9342064. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Horowitz A, Simons M (1998). "Regulation of syndecan-4 phosphorylation in vivo.". J. Biol. Chem. 273 (18): 10914–8. PMID 9556568. 
  • Lee D, Oh ES, Woods A, et al. (1998). "Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate.". J. Biol. Chem. 273 (21): 13022–9. PMID 9582338. 
  • Cohen AR, Woods DF, Marfatia SM, et al. (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.". J. Cell Biol. 142 (1): 129–38. PMID 9660868. 
  • Rusnati M, Tulipano G, Spillmann D, et al. (1999). "Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides.". J. Biol. Chem. 274 (40): 28198–205. PMID 10497173. 
  • Gao Y, Li M, Chen W, Simons M (2000). "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration.". J. Cell. Physiol. 184 (3): 373–9. doi:10.1002/1097-4652(200009)184:3<373::AID-JCP12>3.0.CO;2-I. PMID 10911369. 
  • Tyagi M, Rusnati M, Presta M, Giacca M (2001). "Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans.". J. Biol. Chem. 276 (5): 3254–61. doi:10.1074/jbc.M006701200. PMID 11024024. 
  • Shin J, Lee W, Lee D, et al. (2001). "Solution structure of the dimeric cytoplasmic domain of syndecan-4.". Biochemistry 40 (29): 8471–8. PMID 11456484. 
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