SDC2

From Wikipedia, the free encyclopedia

Syndecan 2

Identifiers

SDC2; HSPG; HSPG1; SYND2

External IDs

OMIM: 142460 MGI: 1349165 HomoloGene: 2253

Gene ontology
Molecular Function:	• molecular_function • cytoskeletal protein binding
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002998 (mRNA)
NP_002989 (protein)

NM_008304 (mRNA)
NP_032330 (protein)

Location

Chr 8: 97.58 - 97.69 Mb

Chr 15: 32.87 - 32.98 Mb

Pubmed search

[1]

[2]

Syndecan 2, also known as SDC2, is a human gene.

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.^[1]

[edit] References

^ Entrez Gene: SDC2 syndecan 2.

[edit] Further reading

Mahley RW, Ji ZS (1999). "Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.". J. Lipid Res. 40 (1): 1–16. PMID 9869645.
Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts.". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7. PMID 1315572.
Marynen P, Zhang J, Cassiman JJ, et al. (1989). "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts.". J. Biol. Chem. 264 (12): 7017–24. PMID 2523388.
Sage H, Vernon RB, Funk SE, et al. (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.". J. Cell Biol. 109 (1): 341–56. PMID 2745554.
Lories V, De Boeck H, David G, et al. (1987). "Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms.". J. Biol. Chem. 262 (2): 854–9. PMID 2948951.
Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor.". Biochemistry 33 (46): 13918–27. PMID 7524669.
Bolton P, Powell J, Rutter M, et al. (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1).". Psychiatr. Genet. 5 (2): 51–5. PMID 7551962.
Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. PMID 7690138.
Lyon M, Deakin JA, Mizuno K, et al. (1994). "Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants.". J. Biol. Chem. 269 (15): 11216–23. PMID 8157651.
David G, Bai XM, Van der Schueren B, et al. (1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development.". Development 119 (3): 841–54. PMID 8187643.
Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor.". Oncogene 12 (2): 289–97. PMID 8570206.
Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, et al. (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system.". J. Cell. Sci. 109 ( Pt 7): 1749–57. PMID 8832397.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Christa L, Carnot F, Simon MT, et al. (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells.". Am. J. Physiol. 271 (6 Pt 1): G993–1002. PMID 8997243.
Rusnati M, Coltrini D, Oreste P, et al. (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size.". J. Biol. Chem. 272 (17): 11313–20. PMID 9111037.
Oh ES, Couchman JR, Woods A (1997). "Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.". Arch. Biochem. Biophys. 344 (1): 67–74. doi:10.1006/abbi.1997.0180. PMID 9244383.
Ishikawa-Brush Y, Powell JF, Bolton P, et al. (1997). "Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene.". Hum. Mol. Genet. 6 (8): 1241–50. PMID 9259269.
Chang HC, Samaniego F, Nair BC, et al. (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region.". AIDS 11 (12): 1421–31. PMID 9342064.
Grootjans JJ, Zimmermann P, Reekmans G, et al. (1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13683–8. PMID 9391086.
Cohen AR, Woods DF, Marfatia SM, et al. (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.". J. Cell Biol. 142 (1): 129–38. PMID 9660868.