SCNN1D

From Wikipedia, the free encyclopedia

Sodium channel, nonvoltage-gated 1, delta

Identifiers

SCNN1D; ENaCd; ENaCdelta; MGC149710; MGC149711; SCNED; dNaCh

External IDs

Gene ontology
Molecular Function:	• ion channel activity • sodium channel activity • amiloride-sensitive sodium channel activity • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane • integral to membrane
Biological Process:	• ion transport • sodium ion transport • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002978 (mRNA)
NP_002969 (protein)

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n/a (protein)

Location

Chr 1: 1.21 - 1.22 Mb

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Pubmed search

[1]

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Sodium channel, nonvoltage-gated 1, delta, also known as SCNN1D, is a human gene.^[1]

[edit] References

^ Entrez Gene: SCNN1D sodium channel, nonvoltage-gated 1, delta.

[edit] Further reading

Waldmann R, Champigny G, Bassilana F, et al. (1996). "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.". J. Biol. Chem. 270 (46): 27411–4. PMID 7499195.
Waldmann R, Bassilana F, Voilley N, et al. (1997). "Assignment of the human amiloride-sensitive Na+ channel delta isoform to chromosome 1p36.3-p36.2.". Genomics 34 (2): 262–3. PMID 8661065.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Biasio W, Chang T, McIntosh CJ, McDonald FJ (2004). "Identification of Murr1 as a regulator of the human delta epithelial sodium channel.". J. Biol. Chem. 279 (7): 5429–34. doi:10.1074/jbc.M311155200. PMID 14645214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamamura H, Ugawa S, Ueda T, et al. (2004). "Protons activate the delta-subunit of the epithelial Na+ channel in humans.". J. Biol. Chem. 279 (13): 12529–34. doi:10.1074/jbc.M400274200. PMID 14726523.
Ji HL, Benos DJ (2004). "Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel.". J. Biol. Chem. 279 (26): 26939–47. doi:10.1074/jbc.M401143200. PMID 15084585.
Yamamura H, Ugawa S, Ueda T, et al. (2004). "Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.". J. Biol. Chem. 279 (43): 44483–9. doi:10.1074/jbc.M408929200. PMID 15308635.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ji HL, Su XF, Kedar S, et al. (2006). "Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction.". J. Biol. Chem. 281 (12): 8233–41. doi:10.1074/jbc.M512293200. PMID 16423824.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Yamamura H, Ugawa S, Ueda T, et al. (2006). "A novel spliced variant of the epithelial Na+ channel delta-subunit in the human brain.". Biochem. Biophys. Res. Commun. 349 (1): 317–21. doi:10.1016/j.bbrc.2006.08.043. PMID 16930535.
Giraldez T, Afonso-Oramas D, Cruz-Muros I, et al. (2007). "Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon.". J. Neurochem. 102 (4): 1304–15. doi:10.1111/j.1471-4159.2007.04622.x. PMID 17472699.