SCGB3A2

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Secretoglobin, family 3A, member 2
Identifiers
Symbol(s) SCGB3A2; LU103; PNSP1; UGRP1
External IDs OMIM: 606531 MGI: 2153470 HomoloGene: 14274
Orthologs
Human Mouse
Entrez 117156 117158
Ensembl ENSG00000164265 ENSMUSG00000038791
Uniprot Q96PL1 Q5D060
Refseq NM_054023 (mRNA)
NP_473364 (protein)		 NM_054038 (mRNA)
NP_473379 (protein)
Location Chr 5: 147.24 - 147.24 Mb Chr 18: 43.89 - 43.89 Mb
Pubmed search [1] [2]

Secretoglobin, family 3A, member 2, also known as SCGB3A2, is a human gene.[1]

In addition to regulating thyroid-specific expression of genes, thyroid transcription factor (TITF1; MIM 600635) controls the transcription of genes specifically expressed in lung, such as surfactant proteins (e.g., SFTPA1; MIM 178630) and uteroglobin (UGB; MIM 192020). Mice lacking Ttf1 die immediately after birth from respiratory failure caused by profoundly hypoplastic lungs (Kimura et al., 1996). The UGRP1 gene encodes a uteroglobin-related protein and is a downstream target of TITF1.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SCGB3A2 secretoglobin, family 3A, member 2.

[edit] Further reading

  • Kimura S, Hara Y, Pineau T, et al. (1996). "The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.". Genes Dev. 10 (1): 60–9. PMID 8557195. 
  • Wattiez R, Hermans C, Cruyt C, et al. (2001). "Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases.". Electrophoresis 21 (13): 2703–12. doi:10.1002/1522-2683(20000701)21:13<2703::AID-ELPS2703>3.0.CO;2-W. PMID 10949149. 
  • Niimi T, Keck-Waggoner CL, Popescu NC, et al. (2002). "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor.". Mol. Endocrinol. 15 (11): 2021–36. PMID 11682631. 
  • Niimi T, Munakata M, Keck-Waggoner CL, et al. (2002). "A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.". Am. J. Hum. Genet. 70 (3): 718–25. PMID 11813133. 
  • Porter D, Lahti-Domenici J, Torres-Arzayus M, et al. (2003). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.". Mech. Dev. 114 (1-2): 201–4. PMID 12175512. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.". J. Immunol. 171 (2): 924–30. PMID 12847263. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Srisodsai A, Kurotani R, Chiba Y, et al. (2005). "Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.". J. Biol. Chem. 279 (52): 54358–68. doi:10.1074/jbc.M405331200. PMID 15485815. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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