SCGB3A1

From Wikipedia, the free encyclopedia

Secretoglobin, family 3A, member 1

Identifiers

SCGB3A1; HIN1; HIN-1; LU105; MGC87867; PnSP-2; UGRP2

External IDs

OMIM: 606500 MGI: 1915912 HomoloGene: 14160

Gene ontology
Molecular Function:	• cytokine activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• negative regulation of cell growth • regulation of cell proliferation

Orthologs

Human

Mouse

Refseq

NM_052863 (mRNA)
NP_443095 (protein)

NM_054037 (mRNA)
NP_473378 (protein)

Location

Chr 5: 179.95 - 179.95 Mb

Chr 11: 49.51 - 49.51 Mb

Pubmed search

[1]

[2]

Secretoglobin, family 3A, member 1, also known as SCGB3A1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1.

[edit] Further reading

Krop IE, Sgroi D, Porter DA, et al. (2001). "HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9796-801. doi:10.1073/pnas.171138398. PMID 11481438.
Porter D, Lahti-Domenici J, Torres-Arzayus M, et al. (2003). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.". Mech. Dev. 114 (1-2): 201-4. PMID 12175512.
Reynolds SD, Reynolds PR, Pryhuber GS, et al. (2003). "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.". Am. J. Respir. Crit. Care Med. 166 (11): 1498-509. doi:10.1164/rccm.200204-285OC. PMID 12406855.
Niimi T, Copeland NG, Gilbert DJ, et al. (2003). "Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family.". Cytogenet. Genome Res. 97 (1-2): 120-7. PMID 12438750.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Krop I, Maguire P, Lahti-Domenici J, et al. (2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.". Cancer Res. 63 (9): 2024-7. PMID 12727813.
Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.". J. Immunol. 171 (2): 924-30. PMID 12847263.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Fackler MJ, McVeigh M, Evron E, et al. (2004). "DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma.". Int. J. Cancer 107 (6): 970-5. doi:10.1002/ijc.11508. PMID 14601057.
Tisserand P, Fouquet C, Barrois M, et al. (2004). "Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors.". Cancer Biol. Ther. 2 (5): 559-63. PMID 14614327.
Marchetti A, Barassi F, Martella C, et al. (2004). "Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome.". Clin. Cancer Res. 10 (4): 1338-43. PMID 14977834.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Krop I, Player A, Tablante A, et al. (2005). "Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types.". Mol. Cancer Res. 2 (9): 489-94. PMID 15383627.
Shigematsu H, Suzuki M, Takahashi T, et al. (2005). "Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.". Int. J. Cancer 113 (4): 600-4. doi:10.1002/ijc.20622. PMID 15472908.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Krop I, Parker MT, Bloushtain-Qimron N, et al. (2005). "HIN-1, an inhibitor of cell growth, invasion, and AKT activation.". Cancer Res. 65 (21): 9659-69. doi:10.1158/0008-5472.CAN-05-1663. PMID 16266985.
Yang Q, Kiernan CM, Tian Y, et al. (2007). "Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.". Clin. Cancer Res. 13 (11): 3191-7. doi:10.1158/1078-0432.CCR-06-2846. PMID 17545522.
Wu Q, Lothe RA, Ahlquist T, et al. (2007). "DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.". Mol. Cancer 6: 45. doi:10.1186/1476-4598-6-45. PMID 17623056.