SCGB1D2

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Secretoglobin, family 1D, member 2
Identifiers
Symbol(s) SCGB1D2; LIPB; LPHB
External IDs HomoloGene: 88740
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10647 n/a
Ensembl ENSG00000124935 n/a
Uniprot O95969 n/a
Refseq NM_006551 (mRNA)
NP_006542 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 11: 61.77 - 61.77 Mb n/a
Pubmed search [1] n/a

Secretoglobin, family 1D, member 2, also known as SCGB1D2, is a human gene.[1]

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.[1]


SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells[2].


[edit] References

  1. ^ a b Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2.
  2. ^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer 13: 1033 – 1067. doi:10.1677/ERC-06-0001. PMID 17158753. 

[edit] Further reading

  • Culleton J, O'Brien N, Ryan BM, et al. (2007). "Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer.". Int. J. Cancer 120 (5): 1087–92. doi:10.1002/ijc.22471. PMID 17163411. 
  • Sjödin A, Guo D, Lund-Johansen M, et al. (2005). "Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas.". Acta Neuropathol. 109 (4): 381–6. doi:10.1007/s00401-004-0972-6. PMID 15668787. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Carter D, Dillon DC, Reynolds LD, et al. (2003). "Serum antibodies to lipophilin B detected in late stage breast cancer patients.". Clin. Cancer Res. 9 (2): 749–54. PMID 12576445. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.". Biochemistry 41 (21): 6714–22. PMID 12022875. 
  • Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein.". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439. 
  • Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears.". FEBS Lett. 432 (3): 163–7. PMID 9720917. 
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