SCEL (gene)

From Wikipedia, the free encyclopedia

Sciellin

Identifiers

SCEL; FLJ21667; MGC22531

External IDs

OMIM: 604112 MGI: 1891228 HomoloGene: 2850

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• cornified envelope • cytoplasm
Biological Process:	• epidermis development • embryonic development • keratinocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003843 (mRNA)
NP_003834 (protein)

NM_022886 (mRNA)
NP_075024 (protein)

Location

Chr 13: 76.85 - 77.12 Mb

Chr 14: 102.4 - 102.5 Mb

Pubmed search

[1]

[2]

Sciellin, also known as SCEL, is a human gene.^[1]

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SCEL sciellin.

[edit] Further reading

Corona W, Karkera DJ, Patterson RH, et al. (2004). "Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma.". Anticancer Res. 24 (3a): 1417-9. PMID 15274303.
Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes.". J. Invest. Dermatol. 121 (4): 781-5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Champliaud MF, Baden HP, Koch M, et al. (2001). "Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties.". Genomics 70 (2): 264-8. doi:10.1006/geno.2000.6390. PMID 11112355.
Champliaud MF, Burgeson RE, Jin W, et al. (1998). "cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope.". J. Biol. Chem. 273 (47): 31547-54. PMID 9813070.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Kvedar JC, Manabe M, Phillips SB, et al. (1992). "Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes.". Differentiation 49 (3): 195-204. PMID 1377656.