SAV1

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Salvador homolog 1 (Drosophila)
PDB rendering based on 2dwv.
Available structures: 2dwv
Identifiers
Symbol(s) SAV1; SAV; WW45; WWP4
External IDs OMIM: 607203 MGI: 1927144 HomoloGene: 32517
Orthologs
Human Mouse
Entrez 60485 64010
Ensembl n/a ENSMUSG00000021067
Uniprot n/a Q8VEB2
Refseq NM_021818 (mRNA)
NP_068590 (protein)		 XM_001000965 (mRNA)
XP_001000965 (protein)
Location n/a Chr 12: 70.88 - 70.91 Mb
Pubmed search [1] [2]

Salvador homolog 1 (Drosophila), also known as SAV1, is a human gene.[1]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.[1]

[edit] References

  1. ^ a b Entrez Gene: SAV1 salvador homolog 1 (Drosophila).

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Valverde P (2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene.". Biochem. Biophys. Res. Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580. 
  • Tapon N, Harvey KF, Bell DW, et al. (2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.". Cell 110 (4): 467–78. PMID 12202036. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yoo NJ, Soung YH, Lee JW, et al. (2003). "Mutational analysis of salvador gene in human carcinomas.". APMIS 111 (6): 595–8. PMID 12969014. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006. 
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  • Callus BA, Verhagen AM, Vaux DL (2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.". FEBS J. 273 (18): 4264–76. doi:10.1111/j.1742-4658.2006.05427.x. PMID 16930133. 
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