SAT2

From Wikipedia, the free encyclopedia

This article is about the human gene. For the submarine communications cable, see SAT-2 (cable system).

Spermidine/spermine N1-acetyltransferase 2

PDB rendering based on 2bei.

Available structures: 2bei

Identifiers

Symbol(s)

SAT2; SSAT2

External IDs

MGI: 1916465 HomoloGene: 44215

Gene ontology
Molecular Function:	• diamine N-acetyltransferase activity • N-acetyltransferase activity • acyltransferase activity • transferase activity

Orthologs

Human

Mouse

Refseq

NM_133491 (mRNA)
NP_597998 (protein)

XM_001001037 (mRNA)
XP_001001037 (protein)

Location

Chr 17: 7.47 - 7.47 Mb

Chr 11: 69.44 - 69.44 Mb

Pubmed search

[1]

[2]

Spermidine/spermine N1-acetyltransferase 2, also known as SAT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2.

[edit] Further reading

Baek JH, Liu YV, McDonald KR, et al. (2008). "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.". J. Biol. Chem. 282 (46): 33358-66. doi:10.1074/jbc.M705627200. PMID 17875644.
Baek JH, Liu YV, McDonald KR, et al. (2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.". J. Biol. Chem. 282 (32): 23572-80. doi:10.1074/jbc.M703504200. PMID 17558023.
Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.". Mol. Cell. Biochem. 298 (1-2): 59-68. doi:10.1007/s11010-006-9350-0. PMID 17119850.
Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006). "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A.". Proteins 64 (1): 288-93. doi:10.1002/prot.20967. PMID 16596569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Coleman CS, Stanley BA, Jones AD, Pegg AE (2005). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism.". Biochem. J. 384 (Pt 1): 139-48. doi:10.1042/BJ20040790. PMID 15283699.
Chen Y, Vujcic S, Liang P, et al. (2003). "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase.". Biochem. J. 373 (Pt 3): 661-7. doi:10.1042/BJ20030734. PMID 12803540.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.