Sarcosine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a sarcosine dehydrogenase (EC 1.5.99.1) is an enzyme that catalyzes the chemical reaction

sarcosine + acceptor + H₂O glycine + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are sarcosine, acceptor, and H₂O, whereas its 3 products are glycine, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is sarcosine:acceptor oxidoreductase (demethylating). Other names in common use include sarcosine N-demethylase, monomethylglycine dehydrogenase, and sarcosine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, FMN.

[edit] References

• IUBMB entry for 1.5.99.1
• BRENDA references for 1.5.99.1 (Recommended.)
• PubMed references for 1.5.99.1
• PubMed Central references for 1.5.99.1
• Google Scholar references for 1.5.99.1
• FRISELL WR, MACKENZIE CG (1962). "Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 237: 94–8. PMID 13895406. 
• HOSKINS DD, MACKENZIE CG (1961). "Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 236: 177–83. PMID 13716069. 

[edit] External links

The CAS registry number for this enzyme class is 37228-65-2.

• IUBMB entry for 1.5.99.1

• KEGG entry for 1.5.99.1

• BRENDA entry for 1.5.99.1

• NiceZyme view of 1.5.99.1

• EC2PDB: PDB structures for 1.5.99.1

• PRIAM entry for 1.5.99.1

• PUMA2 entry for 1.5.99.1

• IntEnz: Integrated Enzyme entry for 1.5.99.1

• MetaCyc entry for 1.5.99.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008480: sarcosine dehydrogenase

• AMIGO entry for GO code 0008480: sarcosine dehydrogenase