SAP30

From Wikipedia, the free encyclopedia

Sin3A-associated protein, 30kDa

Identifiers

External IDs

OMIM: 603378 MGI: 1929129 HomoloGene: 2869

Gene ontology
Molecular Function:	• transcription corepressor activity • protein binding
Cellular Component:	• histone deacetylase complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003864 (mRNA)
NP_003855 (protein)

NM_021788 (mRNA)
NP_068560 (protein)

Location

Chr 4: 174.53 - 174.54 Mb

Chr 8: 60.37 - 60.38 Mb

Pubmed search

[1]

[2]

Sin3A-associated protein, 30kDa, also known as SAP30, is a human gene.^[1]

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.^[1]

[edit] References

^ ^a ^b Entrez Gene: SAP30 Sin3A-associated protein, 30kDa.

[edit] Further reading

Ayer DE, Lawrence QA, Eisenman RN (1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.". Cell 80 (5): 767-76. PMID 7889570.
Zhang Y, Iratni R, Erdjument-Bromage H, et al. (1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.". Cell 89 (3): 357-64. PMID 9150135.
Zhang Y, Sun ZW, Iratni R, et al. (1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.". Mol. Cell 1 (7): 1021-31. PMID 9651585.
Laherty CD, Billin AN, Lavinsky RM, et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.". Mol. Cell 2 (1): 33-42. PMID 9702189.
Zhang Y, LeRoy G, Seelig HP, et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.". Cell 95 (2): 279-89. PMID 9790534.
Tong JK, Hassig CA, Schnitzler GR, et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.". Nature 395 (6705): 917-21. doi:10.1038/27699. PMID 9804427.
Hsieh JJ, Zhou S, Chen L, et al. (1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 23-8. PMID 9874765.
Boutell JM, Thomas P, Neal JW, et al. (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.". Hum. Mol. Genet. 8 (9): 1647-55. PMID 10441327.
Zhang Y, Ng HH, Erdjument-Bromage H, et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev. 13 (15): 1924-35. PMID 10444591.
Krithivas A, Young DB, Liao G, et al. (2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells.". J. Virol. 74 (20): 9637-45. PMID 11000236.
Underhill C, Qutob MS, Yee SP, Torchia J (2001). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.". J. Biol. Chem. 275 (51): 40463-70. doi:10.1074/jbc.M007864200. PMID 11013263.
Humphrey GW, Wang Y, Russanova VR, et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.". J. Biol. Chem. 276 (9): 6817-24. doi:10.1074/jbc.M007372200. PMID 11102443.
Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.". J. Biol. Chem. 276 (12): 8734-9. doi:10.1074/jbc.M007664200. PMID 11118440.
Yochum GS, Ayer DE (2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.". Mol. Cell. Biol. 21 (13): 4110-8. doi:10.1128/MCB.21.13.4110-4118.2001. PMID 11390640.
Kuzmichev A, Zhang Y, Erdjument-Bromage H, et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).". Mol. Cell. Biol. 22 (3): 835-48. PMID 11784859.
Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.". J. Biol. Chem. 277 (38): 35434-9. doi:10.1074/jbc.M203455200. PMID 12124384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wysocka J, Myers MP, Laherty CD, et al. (2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.". Genes Dev. 17 (7): 896-911. doi:10.1101/gad.252103. PMID 12670868.
Huang NE, Lin CH, Lin YS, Yu WC (2003). "Modulation of YY1 activity by SAP30.". Biochem. Biophys. Res. Commun. 306 (1): 267-75. PMID 12788099.
Sironi E, Cerri A, Tomasini D, et al. (2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes.". J. Cutan. Pathol. 31 (4): 318-22. PMID 15005689.