SAM-IV riboswitch
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SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM) [1], a cofactor used in many methylation reactions. Originally identified by bioinformatics [2], SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct.
[edit] References
- ^ Weinberg Z, Regulski EE, Hammond MC, et al (2008). "The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches". RNA. doi:. PMID 18369181.
- ^ Weinberg Z, Barrick JE, Yao Z, et al (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–19. doi:. PMID 17621584.
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