Talk:Salmonella enterica
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[edit] What does S.typhi do?
My book uses the term "toxins", but also talks about "septical metastases". What exactly happens when infected with the bacterium? thanks! 86.85.133.102 12:37, 11 June 2007 (UTC)
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- Toxins can be chemicals released by the bacteria into your body which cause damage beyond just the presence of the bacteria (the infection) itself. I don't think S. typhi secretes a toxin in order to cause its damage. A better example of a toxin producing bacterium is Cornybacterium diphtheriae which causes, as you might guess from the name, diphtheria (the 'D' in the common children's vaccine DTaP). Hope that helps - I've never heard of septical metastases, it might refer to the movement of the bacteria through the lining of the gut into the blood stream, which is how they spread. Jawshoeaw 09:32, 9 July 2007 (UTC)Jawshoeaw
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- I think by "septical metastases" it is referring to the S. typhi's ability to use macrophages and neutrophils as systemic transport. The normal terminology I've heard for this is "systemic dissemination" but my guess is it's the same thing. Essentially what's happening is after host infection, macrophages and neutrophils (white blood cells) find the bacteria and eat it up to digest it but the capsule that encases the bacteria (vi-antigen) protects the bacteria from the lysosomes that would normally kill it. This allows S. typhi to travel around the body using these macrophages and neutrophils until they either die naturally or get killed by the bacteria where it is released into various locations around the body. —Preceding unsigned comment added by ABeydoun (talk • contribs) 05:13, 8 October 2007 (UTC) it's common name is Salmonella and ocurred mostly in the twentieth century
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- Toxins can be chemicals released by the bacteria into your body which cause damage beyond just the presence of the bacteria (the infection) itself. I don't think S. typhi secretes a toxin in order to cause its damage. A better example of a toxin producing bacterium is Cornybacterium diphtheriae which causes, as you might guess from the name, diphtheria (the 'D' in the common children's vaccine DTaP). Hope that helps - I've never heard of septical metastases, it might refer to the movement of the bacteria through the lining of the gut into the blood stream, which is how they spread. Jawshoeaw 09:32, 9 July 2007 (UTC)Jawshoeaw
