Salutaridine synthase

From Wikipedia, the free encyclopedia

In enzymology, a salutaridine synthase (EC 1.14.21.4) is an enzyme that catalyzes the chemical reaction

(R)-reticuline + NADPH + H⁺ + O₂ salutaridine + NADP⁺ + 2 H₂O

The 4 substrates of this enzyme are (R)-reticuline, NADPH, H⁺, and O₂, whereas its 3 products are salutaridine, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling). This enzyme is also called (R)-reticuline oxidase (C-C phenol-coupling). This enzyme participates in alkaloid biosynthesis i.

[edit] References

• IUBMB entry for 1.14.21.4
• BRENDA references for 1.14.21.4 (Recommended.)
• PubMed references for 1.14.21.4
• PubMed Central references for 1.14.21.4
• Google Scholar references for 1.14.21.4
• Gerady R and Zenk MH (1993). "Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum". Phytochemistry 32: 79–86. doi:10.1016/0031-9422(92)80111-Q. 

[edit] External links

The CAS registry number for this enzyme class is 149433-84-1.

• IUBMB entry for 1.14.21.4

• KEGG entry for 1.14.21.4

• BRENDA entry for 1.14.21.4

• NiceZyme view of 1.14.21.4

• EC2PDB: PDB structures for 1.14.21.4

• PRIAM entry for 1.14.21.4

• PUMA2 entry for 1.14.21.4

• IntEnz: Integrated Enzyme entry for 1.14.21.4

• MetaCyc entry for 1.14.21.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047055: salutaridine synthase

• AMIGO entry for GO code 0047055: salutaridine synthase