SAE1

From Wikipedia, the free encyclopedia

SUMO1 activating enzyme subunit 1

PDB rendering based on 1y8q.

Available structures: 1y8q, 1y8r

Identifiers

Symbol(s)

SAE1; AOS1; FLJ3091; HSPC140; SUA1

External IDs

MGI: 1929264 HomoloGene: 4019

Gene ontology
Molecular Function:	• ubiquitin activating enzyme activity • protein C-terminus binding • enzyme activator activity • ligase activity • ATP-dependent protein binding • protein heterodimerization activity
Cellular Component:	• nucleus
Biological Process:	• protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005500 (mRNA)
NP_005491 (protein)

NM_019748 (mRNA)
NP_062722 (protein)

Location

Chr 19: 52.33 - 52.41 Mb

Chr 7: 15.49 - 15.55 Mb

Pubmed search

[1]

[2]

SUMO1 activating enzyme subunit 1, also known as SAE1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1.

[edit] Further reading

Okuma T, Honda R, Ichikawa G, et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.
Desterro JM, Rodriguez MS, Kemp GD, Hay RT (1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.". J. Biol. Chem. 274 (15): 10618–24. PMID 10187858.
Gong L, Li B, Millas S, Yeh ET (1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.". FEBS Lett. 448 (1): 185–9. PMID 10217437.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Tatham MH, Jaffray E, Vaughan OA, et al. (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.". J. Biol. Chem. 276 (38): 35368–74. doi:10.1074/jbc.M104214200. PMID 11451954.
Azuma Y, Tan SH, Cavenagh MM, et al. (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme.". FASEB J. 15 (10): 1825–7. PMID 11481243.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tatham MH, Kim S, Yu B, et al. (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.". Biochemistry 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Komatsu T, Mizusaki H, Mukai T, et al. (2005). "Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.". Mol. Endocrinol. 18 (10): 2451–62. doi:10.1210/me.2004-0173. PMID 15192080.
Salinas S, Briançon-Marjollet A, Bossis G, et al. (2004). "SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.". J. Cell Biol. 165 (6): 767–73. doi:10.1083/jcb.200310136. PMID 15210726.
Lin JY, Ohshima T, Shimotohno K (2004). "Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53.". FEBS Lett. 573 (1-3): 15–8. doi:10.1016/j.febslet.2004.07.059. PMID 15327968.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Boggio R, Colombo R, Hay RT, et al. (2005). "A mechanism for inhibiting the SUMO pathway.". Mol. Cell 16 (4): 549–61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.
Lois LM, Lima CD (2005). "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.". EMBO J. 24 (3): 439–51. doi:10.1038/sj.emboj.7600552. PMID 15660128.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Klenk C, Humrich J, Quitterer U, Lohse MJ (2006). "SUMO-1 controls the protein stability and the biological function of phosducin.". J. Biol. Chem. 281 (13): 8357–64. doi:10.1074/jbc.M513703200. PMID 16421094.
Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.
Pan X, Li H, Zhang P, et al. (2006). "Ubc9 interacts with SOX4 and represses its transcriptional activity.". Biochem. Biophys. Res. Commun. 344 (3): 727–34. doi:10.1016/j.bbrc.2006.03.194. PMID 16631117.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.