Saccharopine dehydrogenase (NADP+, L-glutamate-forming)

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In enzymology, a saccharopine dehydrogenase (NADP+, L-glutamate-forming) (EC 1.5.1.10) is an enzyme that catalyzes the chemical reaction

N₆-(L-1,3-dicarboxypropyl)-L-lysine + NADP⁺ + H₂O L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH + H⁺

The 3 substrates of this enzyme are N6-(L-1,3-dicarboxypropyl)-L-lysine, NADP⁺, and H₂O, whereas its 4 products are L-glutamate, L-2-aminoadipate 6-semialdehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming). Other names in common use include saccharopine (nicotinamide adenine dinucleotide phosphate,, glutamate-forming) dehydrogenase, aminoadipic semialdehyde-glutamic reductase, aminoadipate semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamate reductase, epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase, (L-2-aminoadipate-semialdehyde forming), saccharopine reductase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase, and (L-glutamate-forming). This enzyme participates in lysine biosynthesis and lysine degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1E5L, 1E5Q, and 2AXQ.

[edit] References

• IUBMB entry for 1.5.1.10
• BRENDA references for 1.5.1.10 (Recommended.)
• PubMed references for 1.5.1.10
• PubMed Central references for 1.5.1.10
• Google Scholar references for 1.5.1.10
• Jones EE, Broquist HP (1966). "Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase". J. Biol. Chem. 241: 3430–4. PMID 4380448. 

[edit] External links

The CAS registry number for this enzyme class is 9033-55-0.

• IUBMB entry for 1.5.1.10

• KEGG entry for 1.5.1.10

• BRENDA entry for 1.5.1.10

• NiceZyme view of 1.5.1.10

• EC2PDB: PDB structures for 1.5.1.10

• PRIAM entry for 1.5.1.10

• PUMA2 entry for 1.5.1.10

• IntEnz: Integrated Enzyme entry for 1.5.1.10

• MetaCyc entry for 1.5.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004755: saccharopine dehydrogenase (NADP+, L-glutamate-forming)

• AMIGO entry for GO code 0004755: saccharopine dehydrogenase (NADP+, L-glutamate-forming)