S100 calcium binding protein A8

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S100 calcium binding protein A8
PDB rendering based on 1mr8.
Available structures: 1mr8, 1xk4
Identifiers
Symbol(s) S100A8; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MRP8; NIF; P8
External IDs OMIM: 123885 MGI: 88244 HomoloGene: 2225
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6279 20201
Ensembl ENSG00000143546 ENSMUSG00000056054
Uniprot P05109 Q53X15
Refseq NM_002964 (mRNA)
NP_002955 (protein)		 NM_013650 (mRNA)
NP_038678 (protein)
Location Chr 1: 151.63 - 151.63 Mb Chr 3: 90.76 - 90.76 Mb
Pubmed search [1] [2]

S100 calcium binding protein A8, also known as S100A8, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.[2]

[edit] References

  1. ^ Entrez Gene: S100A8 S100 calcium binding protein A8.
  2. ^ Entrez Gene: S100A8 S100 calcium binding protein A8.

[edit] Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470. 
  • Kerkhoff C, Klempt M, Sorg C (1999). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9).". Biochim. Biophys. Acta 1448 (2): 200–11. PMID 9920411. 
  • Nacken W, Roth J, Sorg C, Kerkhoff C (2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity.". Microsc. Res. Tech. 60 (6): 569–80. doi:10.1002/jemt.10299. PMID 12645005. 
  • Roth J, Vogl T, Sorg C, Sunderkötter C (2004). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.". Trends Immunol. 24 (4): 155–8. PMID 12697438. 
  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667. 
  • Lemarchand P, Vaglio M, Mauël J, Markert M (1992). "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation.". J. Biol. Chem. 267 (27): 19379–82. PMID 1326551. 
  • Schäfer T, Sachse GE, Gassen HG (1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells.". Biol. Chem. Hoppe-Seyler 372 (1): 1–4. PMID 2039599. 
  • Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3.". Genomics 8 (3): 420–6. PMID 2149559. 
  • Wilkinson MM, Busuttil A, Hayward C, et al. (1989). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues.". J. Cell. Sci. 91 ( Pt 2): 221–30. PMID 3267695. 
  • Odink K, Cerletti N, Brüggen J, et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.". Nature 330 (6143): 80–2. doi:10.1038/330080a0. PMID 3313057. 
  • Lagasse E, Clerc RG (1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.". Mol. Cell. Biol. 8 (6): 2402–10. PMID 3405210. 
  • Dorin JR, Novak M, Hill RE, et al. (1987). "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene.". Nature 326 (6113): 614–7. doi:10.1038/326614a0. PMID 3561500. 
  • Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097. 
  • Umekawa T, Kurita T (1995). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone.". Biochem. Mol. Biol. Int. 34 (2): 309–13. PMID 7849642. 
  • Engelkamp D, Schäfer BW, Mattei MG, et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667. 
  • Roth J, Burwinkel F, van den Bos C, et al. (1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner.". Blood 82 (6): 1875–83. PMID 8400238. 
  • Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.". J. Dent. Res. 72 (2): 517–23. PMID 8423249. 
  • Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin.". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876. 
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