S100A9

From Wikipedia, the free encyclopedia

S100 calcium binding protein A9

PDB rendering based on 1irj.

Available structures: 1irj, 1xk4

Identifiers

Symbol(s)

S100A9; MIF; 60B8AG; CFAG; NIF; CAGB; CGLB; L1AG; LIAG; MAC387; MRP14; P14

External IDs

OMIM: 123886 MGI: 1338947 HomoloGene: 2227

Gene ontology
Molecular Function:	• signal transducer activity • calcium ion binding
Cellular Component:	• extracellular space
Biological Process:	• inflammatory response • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002965 (mRNA)
NP_002956 (protein)

NM_009114 (mRNA)
NP_033140 (protein)

Location

Chr 1: 151.6 - 151.6 Mb

Chr 3: 90.78 - 90.78 Mb

Pubmed search

[1]

[2]

S100 calcium binding protein A9, also known as S100A9, is a human gene.^[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.^[1]

[edit] See also

S-100 protein

[edit] References

^ ^a ^b Entrez Gene: S100A9 S100 calcium binding protein A9.

[edit] Further reading

Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
Kerkhoff C, Klempt M, Sorg C (1999). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9).". Biochim. Biophys. Acta 1448 (2): 200–11. PMID 9920411.
Nacken W, Roth J, Sorg C, Kerkhoff C (2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity.". Microsc. Res. Tech. 60 (6): 569–80. doi:10.1002/jemt.10299. PMID 12645005.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667.
Longbottom D, Sallenave JM, van Heyningen V (1992). "Subunit structure of calgranulins A and B obtained from sputum, plasma, granulocytes and cultured epithelial cells.". Biochim. Biophys. Acta 1120 (2): 215–22. PMID 1562590.
Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3.". Genomics 8 (3): 420–6. PMID 2149559.
Edgeworth J, Freemont P, Hogg N (1989). "Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.". Nature 342 (6246): 189–92. doi:10.1038/342189a0. PMID 2478889.
Murao S, Collart FR, Huberman E (1989). "A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases.". J. Biol. Chem. 264 (14): 8356–60. PMID 2656677.
Odink K, Cerletti N, Brüggen J, et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.". Nature 330 (6143): 80–2. doi:10.1038/330080a0. PMID 3313057.
Lagasse E, Clerc RG (1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.". Mol. Cell. Biol. 8 (6): 2402–10. PMID 3405210.
Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097.
Engelkamp D, Schäfer BW, Mattei MG, et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667.
Roth J, Burwinkel F, van den Bos C, et al. (1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner.". Blood 82 (6): 1875–83. PMID 8400238.
Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.". J. Dent. Res. 72 (2): 517–23. PMID 8423249.
Newton RA, Hogg N (1998). "The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils.". J. Immunol. 160 (3): 1427–35. PMID 9570563.
Vogl T, Pröpper C, Hartmann M, et al. (1999). "S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14.". J. Biol. Chem. 274 (36): 25291–6. PMID 10464253.
Kerkhoff C, Klempt M, Kaever V, Sorg C (2000). "The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils.". J. Biol. Chem. 274 (46): 32672–9. PMID 10551823.
Stulík J, Koupilova K, Osterreicher J, et al. (2000). "Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma.". Electrophoresis 20 (18): 3638–46. doi:10.1002/(SICI)1522-2683(19991201)20:18<3638::AID-ELPS3638>3.0.CO;2-W. PMID 10612291.