S100A5

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S100 calcium binding protein A5
Identifiers
Symbol(s) S100A5; S100D
External IDs OMIM: 176991 MGI: 1338915 HomoloGene: 2224
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6276 20199
Ensembl ENSG00000196420 ENSMUSG00000001023
Uniprot P33763 Q149U2
Refseq NM_002962 (mRNA)
NP_002953 (protein)		 NM_011312 (mRNA)
NP_035442 (protein)
Location Chr 1: 151.78 - 151.78 Mb Chr 3: 90.7 - 90.7 Mb
Pubmed search [1] [2]

S100 calcium binding protein A5, also known as S100A5, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.[1]

[edit] References

  1. ^ a b Entrez Gene: S100A5 S100 calcium binding protein A5.

[edit] Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470. 
  • Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097. 
  • Engelkamp D, Schäfer BW, Mattei MG, et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667. 
  • Ridinger K, Ilg EC, Niggli FK, et al. (1999). "Clustered organization of S100 genes in human and mouse.". Biochim. Biophys. Acta 1448 (2): 254–63. PMID 9920416. 
  • Schäfer BW, Fritschy JM, Murmann P, et al. (2000). "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily.". J. Biol. Chem. 275 (39): 30623–30. doi:10.1074/jbc.M002260200. PMID 10882717. 
  • Bronckart Y, Decaestecker C, Nagy N, et al. (2002). "Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins.". Histol. Histopathol. 16 (3): 707–12. PMID 11510959. 
  • Teratani T, Watanabe T, Yamahara K, et al. (2002). "Restricted expression of calcium-binding protein S100A5 in human kidney.". Biochem. Biophys. Res. Commun. 291 (3): 623–7. doi:10.1006/bbrc.2002.6494. PMID 11855835. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chan WY, Xia CL, Dong DC, et al. (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex.". Microsc. Res. Tech. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
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