S100A13

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S100 calcium binding protein A13
PDB rendering based on 1yur.
Available structures: 1yur, 1yus, 1yut, 1yuu, 2h2k
Identifiers
Symbol(s) S100A13;
External IDs OMIM: 601989 MGI: 109581 HomoloGene: 7523
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6284 20196
Ensembl ENSG00000189171 ENSMUSG00000042312
Uniprot Q99584 Q545H7
Refseq NM_001024210 (mRNA)
NP_001019381 (protein)		 NM_009113 (mRNA)
NP_033139 (protein)
Location Chr 1: 151.86 - 151.87 Mb Chr 3: 90.6 - 90.61 Mb
Pubmed search [1] [2]

S100 calcium binding protein A13, also known as S100A13, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: S100A13 S100 calcium binding protein A13.

[edit] Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  • Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097. 
  • Wicki R, Schäfer BW, Erne P, Heizmann CW (1996). "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family.". Biochem. Biophys. Res. Commun. 227 (2): 594–9. doi:10.1006/bbrc.1996.1551. PMID 8878558. 
  • Wicki R, Marenholz I, Mischke D, et al. (1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.". Cell Calcium 20 (6): 459–64. PMID 8985590. 
  • Mouta Carreira C, LaVallee TM, Tarantini F, et al. (1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro.". J. Biol. Chem. 273 (35): 22224–31. PMID 9712836. 
  • Ridinger K, Schäfer BW, Durussel I, et al. (2000). "S100A13. Biochemical characterization and subcellular localization in different cell lines.". J. Biol. Chem. 275 (12): 8686–94. PMID 10722710. 
  • Landriscina M, Bagalá C, Mandinova A, et al. (2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.". J. Biol. Chem. 276 (27): 25549–57. doi:10.1074/jbc.M102925200. PMID 11432880. 
  • Hsieh HL, Schäfer BW, Cox JA, Heizmann CW (2003). "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells.". J. Cell. Sci. 115 (Pt 15): 3149–58. PMID 12118070. 
  • Prudovsky I, Bagala C, Tarantini F, et al. (2002). "The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export.". J. Cell Biol. 158 (2): 201–8. doi:10.1083/jcb.200203084. PMID 12135982. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chan WY, Xia CL, Dong DC, et al. (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex.". Microsc. Res. Tech. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008. 
  • Mandinova A, Soldi R, Graziani I, et al. (2004). "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.". J. Cell. Sci. 116 (Pt 13): 2687–96. doi:10.1242/jcs.00471. PMID 12746488. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Hsieh HL, Schäfer BW, Weigle B, Heizmann CW (2004). "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells.". Biochem. Biophys. Res. Commun. 316 (3): 949–59. doi:10.1016/j.bbrc.2004.02.135. PMID 15033494. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
  • Hayrabedyan S, Kyurkchiev S, Kehayov I (2005). "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis.". Reproductive biology 5 (1): 51–67. PMID 15821778. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
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