S100A11

From Wikipedia, the free encyclopedia

S100 calcium binding protein A11

Identifiers

S100A11; MLN70; S100C

External IDs

OMIM: 603114 MGI: 3645720 HomoloGene: 55916

Gene ontology
Molecular Function:	• calcium ion binding • protein homodimerization activity • S100 beta binding • calcium-dependent protein binding
Cellular Component:	• ruffle • nucleus • cytoplasm
Biological Process:	• signal transduction • negative regulation of DNA replication • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005620 (mRNA)
NP_005611 (protein)

XM_204772 (mRNA)
XP_204772 (protein)

Location

Chr 1: 150.27 - 150.28 Mb

Chr 12: 74.88 - 74.88 Mb

Pubmed search

[1]

[2]

S100 calcium binding protein A11, also known as S100A11, is a human gene.^[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.^[1]

[edit] References

^ ^a ^b Entrez Gene: S100A11 S100 calcium binding protein A11.

[edit] Further reading

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667.
Tomasetto C, Régnier C, Moog-Lutz C, et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097.
Tanaka M, Adzuma K, Iwami M, et al. (1995). "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis.". Cancer Lett. 89 (2): 195–200. PMID 7889529.
Mailliard WS, Haigler HT, Schlaepfer DD (1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I.". J. Biol. Chem. 271 (2): 719–25. PMID 8557678.
Wicki R, Marenholz I, Mischke D, et al. (1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.". Cell Calcium 20 (6): 459–64. PMID 8985590.
Seemann J, Weber K, Gerke V (1997). "Annexin I targets S100C to early endosomes.". FEBS Lett. 413 (1): 185–90. PMID 9287141.
Inada H, Naka M, Tanaka T, et al. (1999). "Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization.". Biochem. Biophys. Res. Commun. 263 (1): 135–8. doi:10.1006/bbrc.1999.1319. PMID 10486266.
Réty S, Osterloh D, Arié JP, et al. (2000). "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.". Structure 8 (2): 175–84. PMID 10673436.
Sakaguchi M, Miyazaki M, Inoue Y, et al. (2000). "Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.". J. Cell Biol. 149 (6): 1193–206. PMID 10851017.
Deloulme JC, Assard N, Mbele GO, et al. (2001). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo.". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
Ruse M, Lambert A, Robinson N, et al. (2001). "S100A7, S100A10, and S100A11 are transglutaminase substrates.". Biochemistry 40 (10): 3167–73. PMID 11258932.
Kondo A, Sakaguchi M, Makino E, et al. (2002). "Localization of S100C immunoreactivity in various human tissues.". Acta Med. Okayama 56 (1): 31–4. PMID 11873942.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bianchi R, Giambanco I, Arcuri C, Donato R (2003). "Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments.". Microsc. Res. Tech. 60 (6): 639–51. doi:10.1002/jemt.10305. PMID 12645011.
Broome AM, Ryan D, Eckert RL (2003). "S100 protein subcellular localization during epidermal differentiation and psoriasis.". J. Histochem. Cytochem. 51 (5): 675–85. PMID 12704215.
Sakaguchi M, Miyazaki M, Takaishi M, et al. (2004). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.". J. Cell Biol. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMID 14623863.
Broome AM, Eckert RL (2004). "Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor.". J. Invest. Dermatol. 122 (1): 29–38. doi:10.1046/j.0022-202X.2003.22105.x. PMID 14962086.
Sakaguchi M, Miyazaki M, Sonegawa H, et al. (2004). "PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11.". J. Cell Biol. 164 (7): 979–84. doi:10.1083/jcb.200312041. PMID 15051732.
Mori M, Shimada H, Gunji Y, et al. (2004). "S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer.". Oncol. Rep. 11 (6): 1287–93. PMID 15138568.