S-ribosylhomocysteine lyase
From Wikipedia, the free encyclopedia
In enzymology, a S-ribosylhomocysteine lyase (EC 4.4.1.21) is an enzyme that catalyzes the chemical reaction
- S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione
Hence, this enzyme has one substrate, S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, and two products, L-homocysteine and (4S)-4,5-dihydroxypentan-2,3-dione.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]. Other names in common use include S-ribosylhomocysteinase, and LuxS. This enzyme participates in methionine metabolism.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1JQW, 2FQO, and 2FQT.
[edit] References
- IUBMB entry for 4.4.1.21
- BRENDA references for 4.4.1.21 (Recommended.)
- PubMed references for 4.4.1.21
- PubMed Central references for 4.4.1.21
- Google Scholar references for 4.4.1.21
- Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D (2003). "S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein". Biochemistry. 42: 4717–26. doi:. PMID 12705835.
- Miller MB, Bassler BL (2001). "Quorum sensing in bacteria". Annu. Rev. Microbiol. 55: 165–99. doi:. PMID 11544353.
[edit] External links
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- The CAS registry number for this enzyme class is 37288-63-4.
[edit] Gene Ontology (GO) codes
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