S-methyl-5-thioribose-1-phosphate isomerase

From Wikipedia, the free encyclopedia

In enzymology, a S-methyl-5-thioribose-1-phosphate isomerase (EC 5.3.1.23) is an enzyme that catalyzes the chemical reaction

S-methyl-5-thio-alpha-D-ribose 1-phosphate S-methyl-5-thio-D-ribulose 1-phosphate

Hence, this enzyme has one substrate, S-methyl-5-thio-alpha-D-ribose 1-phosphate, and one product, S-methyl-5-thio-D-ribulose 1-phosphate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase. Other names in common use include methylthioribose 1-phosphate isomerase, 1-PMTR isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate, aldose-ketose-isomerase, 1-phospho-5'-S-methylthioribose isomerase, and S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase. This enzyme participates in methionine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T9K and 1W2W.

[edit] References

• IUBMB entry for 5.3.1.23
• BRENDA references for 5.3.1.23 (Recommended.)
• PubMed references for 5.3.1.23
• PubMed Central references for 5.3.1.23
• Google Scholar references for 5.3.1.23
• RH (1984). "Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma". J. Biol. Chem. 259: 6715–9. PMID 6725268. 
• Trackman PC, Abeles RH (1983). "Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose". J. Biol. Chem. 258: 6717–20. PMID 6853500. 
• Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263: 9598–606. PMID 2838472. 

[edit] External links

The CAS registry number for this enzyme class is 91608-95-6.

• IUBMB entry for 5.3.1.23

• KEGG entry for 5.3.1.23

• BRENDA entry for 5.3.1.23

• NiceZyme view of 5.3.1.23

• EC2PDB: PDB structures for 5.3.1.23

• PRIAM entry for 5.3.1.23

• PUMA2 entry for 5.3.1.23

• IntEnz: Integrated Enzyme entry for 5.3.1.23

• MetaCyc entry for 5.3.1.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046523: S-methyl-5-thioribose-1-phosphate isomerase

• AMIGO entry for GO code 0046523: S-methyl-5-thioribose-1-phosphate isomerase