S-formylglutathione hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a S-formylglutathione hydrolase (EC 3.1.2.12) is an enzyme that catalyzes the chemical reaction

S-formylglutathione + H₂O glutathione + formate

Thus, the two substrates of this enzyme are S-formylglutathione and H₂O, whereas its two products are glutathione and formate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is S-formylglutathione hydrolase. This enzyme participates in methane metabolism.

[edit] References

• IUBMB entry for 3.1.2.12
• BRENDA references for 3.1.2.12 (Recommended.)
• PubMed references for 3.1.2.12
• PubMed Central references for 3.1.2.12
• Google Scholar references for 3.1.2.12
• Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases". Biochemistry. 12: 3938–43. doi:10.1021/bi00744a024. PMID 4200890. 
• Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver". J. Biol. Chem. 249: 7664–72. PMID 4436331. 
• Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?". J. Bacteriol. 178: 6296–9. PMID 8892832. 

[edit] External links

The CAS registry number for this enzyme class is 50812-21-0.

• IUBMB entry for 3.1.2.12

• KEGG entry for 3.1.2.12

• BRENDA entry for 3.1.2.12

• NiceZyme view of 3.1.2.12

• EC2PDB: PDB structures for 3.1.2.12

• PRIAM entry for 3.1.2.12

• PUMA2 entry for 3.1.2.12

• IntEnz: Integrated Enzyme entry for 3.1.2.12

• MetaCyc entry for 3.1.2.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018738: S-formylglutathione hydrolase

• AMIGO entry for GO code 0018738: S-formylglutathione hydrolase