RYK (gene)
From Wikipedia, the free encyclopedia
RYK receptor-like tyrosine kinase
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Identifiers | ||||||||||||||
Symbol(s) | RYK; D3S3195; JTK5; JTK5A; RYK1 | |||||||||||||
External IDs | OMIM: 600524 MGI: 101766 HomoloGene: 68287 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 6259 | 20187 | ||||||||||||
Ensembl | ENSG00000163785 | ENSMUSG00000032547 | ||||||||||||
Uniprot | P34925 | Q71UK0 | ||||||||||||
Refseq | XM_001130617 (mRNA) XP_001130617 (protein) |
XM_978368 (mRNA) XP_983462 (protein) |
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Location | Chr 3: 135.36 - 135.45 Mb | Chr 9: 102.69 - 102.77 Mb | ||||||||||||
Pubmed search | [1] | [2] |
RYK receptor-like tyrosine kinase, also known as RYK, is a human gene.[1]
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.[1]
[edit] References
[edit] Further reading
- Partanen J, Mäkelä TP, Alitalo R, et al. (1991). "Putative tyrosine kinases expressed in K-562 human leukemia cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913-7. PMID 2247464.
- Gough NM, Rakar S, Hovens CM, Wilks A (1995). "Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.". Mamm. Genome 6 (4): 255-6. PMID 7613029.
- Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403-10. PMID 8247543.
- Stacker SA, Hovens CM, Vitali A, et al. (1993). "Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).". Oncogene 8 (5): 1347-56. PMID 8386829.
- Tamagnone L, Partanen J, Armstrong E, et al. (1993). "The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.". Oncogene 8 (7): 2009-14. PMID 8390040.
- Wang XC, Katso R, Butler R, et al. (1996). "H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.". Mol. Med. 2 (2): 189-203. PMID 8726462.
- Katso RM, Russell RB, Ganesan TS (1999). "Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.". Mol. Cell. Biol. 19 (9): 6427-40. PMID 10454588.
- Trivier E, Ganesan TS (2002). "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.". J. Biol. Chem. 277 (25): 23037-43. doi: . PMID 11956217.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi: . PMID 15146197.
- Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.". Cell 119 (1): 97-108. doi: . PMID 15454084.
- Watanabe A, Akita S, Tin NT, et al. (2006). "A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate.". Cleft Palate Craniofac. J. 43 (3): 310-6. doi: . PMID 16681403.
- Szafranski K, Schindler S, Taudien S, et al.. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." 8 (8): R154. doi: . PMID 17672918.