RYBP

From Wikipedia, the free encyclopedia

RING1 and YY1 binding protein

Identifiers

RYBP; AAP1; DEDAF; YEAF1

External IDs

OMIM: 607535 MGI: 1929059 HomoloGene: 8159

Gene ontology
Molecular Function:	• DNA binding • transcription corepressor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • apoptosis • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012234 (mRNA)
NP_036366 (protein)

NM_019743 (mRNA)
NP_062717 (protein)

Location

Chr 3: 72.51 - 72.58 Mb

n/a

Pubmed search

[1]

[2]

RING1 and YY1 binding protein, also known as RYBP, is a human gene.^[1]

[edit] References

^ Entrez Gene: RYBP RING1 and YY1 binding protein.

[edit] Further reading

Zhu J, Shore SK (1997). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein.". Mol. Cell. Biol. 16 (12): 7054-62. PMID 8943360.
García E, Marcos-Gutiérrez C, del Mar Lorente M, et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.". EMBO J. 18 (12): 3404-18. doi:10.1093/emboj/18.12.3404. PMID 10369680.
Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519-24. doi:10.1073/pnas.041597698. PMID 11171983.
Zheng L, Schickling O, Peter ME, Lenardo MJ (2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.". J. Biol. Chem. 276 (34): 31945-52. doi:10.1074/jbc.M102799200. PMID 11395500.
Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.". J. Biol. Chem. 277 (25): 22484-90. doi:10.1074/jbc.M203060200. PMID 11953439.
Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". EMBO J. 21 (21): 5775-86. PMID 12411495.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Guelen L, Paterson H, Gäken J, et al. (2004). "TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.". Oncogene 23 (5): 1153-65. doi:10.1038/sj.onc.1207224. PMID 14691460.
Danen-van Oorschot AA, Voskamp P, Seelen MC, et al. (2005). "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing.". Cell Death Differ. 11 (5): 564-73. doi:10.1038/sj.cdd.4401391. PMID 14765135.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.