RUNX3

From Wikipedia, the free encyclopedia


Runt-related transcription factor 3
PDB rendering based on 1cmo.
Available structures: 1cmo, 1co1, 1e50, 1ean, 1eao, 1eaq, 1h9d, 1hjb, 1hjc, 1io4, 1ljm
Identifiers
Symbol(s) RUNX3; AML2; CBFA3; FLJ34510; MGC16070; PEBP2aC
External IDs OMIM: 600210 MGI: 102672 HomoloGene: 37914
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 864 12399
Ensembl ENSG00000020633 ENSMUSG00000070691
Uniprot Q13761 O88674
Refseq NM_001031680 (mRNA)
NP_001026850 (protein)		 NM_019732 (mRNA)
NP_062706 (protein)
Location Chr 1: 25.1 - 25.16 Mb Chr 4: 134.39 - 134.45 Mb
Pubmed search [1] [2]

Runt-related transcription factor 3, also known as RUNX3, is a human gene.

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: RUNX3 runt-related transcription factor 3.

[edit] Further reading

  • Vogiatzi P, De Falco G, Claudio PP, Giordano A (2007). "How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions.". Cancer Biol. Ther. 5 (4): 371–4. PMID 16627973. 
  • Wijmenga C, Speck NA, Dracopoli NC, et al. (1995). "Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.". Genomics 26 (3): 611–4. PMID 7607690. 
  • Bae SC, Takahashi E, Zhang YW, et al. (1995). "Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.". Gene 159 (2): 245–8. PMID 7622058. 
  • Levanon D, Negreanu V, Bernstein Y, et al. (1995). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.". Genomics 23 (2): 425–32. doi:10.1006/geno.1994.1519. PMID 7835892. 
  • Bae SC, Yamaguchi-Iwai Y, Ogawa E, et al. (1993). "Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.". Oncogene 8 (3): 809–14. PMID 8437866. 
  • Levanon D, Goldstein RE, Bernstein Y, et al. (1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. PMID 9751710. 
  • Bangsow C, Rubins N, Glusman G, et al. (2002). "The RUNX3 gene--sequence, structure and regulated expression.". Gene 279 (2): 221–32. PMID 11733147. 
  • Li QL, Ito K, Sakakura C, et al. (2002). "Causal relationship between the loss of RUNX3 expression and gastric cancer.". Cell 109 (1): 113–24. PMID 11955451. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Waki T, Tamura G, Sato M, et al. (2003). "Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia.". Cancer Sci. 94 (4): 360–4. PMID 12824905. 
  • Puig-Kröger A, Sanchez-Elsner T, Ruiz N, et al. (2004). "RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements.". Blood 102 (9): 3252–61. doi:10.1182/blood-2003-02-0618. PMID 12855590. 
  • Kato N, Tamura G, Fukase M, et al. (2003). "Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants.". Am. J. Pathol. 163 (2): 387–91. PMID 12875960. 
  • Yang N, Zhang L, Zhang Y, Kazazian HH (2004). "An important role for RUNX3 in human L1 transcription and retrotransposition.". Nucleic Acids Res. 31 (16): 4929–40. PMID 12907736. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Li QL, Kim HR, Kim WJ, et al. (2004). "Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.". Biochem. Biophys. Res. Commun. 314 (1): 223–8. PMID 14715269. 
  • Xiao WH, Liu WW (2004). "Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma.". World J. Gastroenterol. 10 (3): 376–80. PMID 14760761. 
  • Oshimo Y, Oue N, Mitani Y, et al. (2004). "Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma.". Pathobiology 71 (3): 137–43. doi:10.1159/000076468. PMID 15051926. 
  • Jin YH, Jeon EJ, Li QL, et al. (2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.". J. Biol. Chem. 279 (28): 29409–17. doi:10.1074/jbc.M313120200. PMID 15138260. 
  • Ku JL, Kang SB, Shin YK, et al. (2004). "Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines.". Oncogene 23 (40): 6736–42. doi:10.1038/sj.onc.1207731. PMID 15273736. 
  • Sakakura C, Hagiwara A, Miyagawa K, et al. (2005). "Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.". Int. J. Cancer 113 (2): 221–8. doi:10.1002/ijc.20551. PMID 15386419. 

[edit] External links

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD